Ventilation-perfusion distribution in normal subjects
Ventilation-perfusion distribution in normal subjects
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DOI：
10.1152/japplphysiol.00163.2012
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发表时间：
2012-09-01
影响因子：
3.3
通讯作者：
Wilson, Theodore A.
中科院分区：
文献类型：
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作者：
Beck, Kenneth C.;Johnson, Bruce D.;Wilson, Theodore A.
Beck KC，约翰逊BD，奥尔森TP，威尔逊TA.正常人的通气-灌注分布。J Appl Physiol 113：872-877，2012.首次发表于2012年7月5日; doi：10.1152/japplphysiol.00163.2012.-通气分布的LogSD的函数值（sigma（（V）over dot））以前已经报道过，但灌注分布的LogSD的函数值（sigma（（q）over dot））和通气与灌注之间的相关系数（rho）尚未在人体中测量。在这里，我们报告sigma（（V）over dot）的值。σ（（q）除以点），以及从三种气体（氦气和两种可溶气体（乙炔和二甲醚））的洗入数据获得的ρ。正常受试者吸入含有测试气体的气体，并且在前10次呼吸期间呼气末的气体浓度在受试者休息和增加运动水平时进行测量。通气和灌注的区域分布通过具有参数sigma（（V）over dot）、sigma（（q）over dot）和rho的双变量对数正态分布来描述，并且通过将针对该分布计算的呼出气体浓度值与测量值匹配来评价这些参数。获得心输出量和LogSD通气/灌注值（（V）over dotA/（Q）over dot）。静止时，sigma（（q）对点）较高（1.08 +/- 0.12）。随着通气的开始，sigma（（q）对点）下降到0.85 +/- 0.09，但在所有运动水平下仍高于sigma（（V）对点）（0.43 +/- 0.09）。Rho增加到0.87 +/- 0.07，并且对于轻度和中度运动，LogSD（V）对点A/（Q）对点的值主要是sigma（（q）对点）和sigma（（V）对点）的幅度之间的差异的结果。在已知参数值的情况下，双变量分布描述了通气和灌注的综合分布，其是（V）对点A/（Q）对点比率的分布的基础。
Beck KC, Johnson BD, Olson TP, Wilson TA. Ventilation-perfusion distribution in normal subjects. J Appl Physiol 113: 872-877, 2012. First published July 5, 2012; doi: 10.1152/japplphysiol.00163.2012.-Functional values of LogSD of the ventilation distribution (sigma((V) over dot)) have been reported previously, but functional values of LogSD of the perfusion distribution (sigma((q) over dot)) and the coefficient of correlation between ventilation and perfusion (rho) have not been measured in humans. Here, we report values for sigma((V) over dot)., sigma((q) over dot), and rho obtained from wash-in data for three gases, helium and two soluble gases, acetylene and dimethyl ether. Normal subjects inspired gas containing the test gases, and the concentrations of the gases at end-expiration during the first 10 breaths were measured with the subjects at rest and at increasing levels of exercise. The regional distribution of ventilation and perfusion was described by a bivariate log-normal distribution with parameters sigma((V) over dot), sigma((q) over dot), and rho, and these parameters were evaluated by matching the values of expired gas concentrations calculated for this distribution to the measured values. Values of cardiac output and LogSD ventilation/perfusion ((V) over dotA/(Q) over dot) were obtained. At rest, sigma((q) over dot) is high (1.08 +/- 0.12). With the onset of ventilation, sigma((q) over dot) decreases to 0.85 +/- 0.09 but remains higher than sigma((V) over dot) (0.43 +/- 0.09) at all exercise levels. Rho increases to 0.87 +/- 0.07, and the value of LogSD (V) over dotA/(Q) over dot for light and moderate exercise is primarily the result of the difference between the magnitudes of sigma((q) over dot) and sigma((V) over dot). With known values for the parameters, the bivariate distribution describes the comprehensive distribution of ventilation and perfusion that underlies the distribution of the (V) over dotA/(Q) over dot ratio.