Hepatic Epithelioid Hemangioendothelioma: Long-Term Results of Surgical Management
Hepatic Epithelioid Hemangioendothelioma: Long-Term Results of Surgical Management
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DOI：
10.1002/jso.21132
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发表时间：
2008-11-01
影响因子：
2.5
通讯作者：
Baulieux, Jacques
中科院分区：
文献类型：
--
作者：
Mosoia, Liviu;Mabrut, Jean-Yves;Baulieux, Jacques
背景和目的：肝上皮样血管内皮瘤是一种罕见的肝脏血管肿瘤。它的治疗管理仍然很难用治疗意图来定义。本研究的目的是报告手术治疗的病人的长期结果。方法：从1990年到2006年，9例病人(25岁-)被纳入本研究。肝内病变范围为单叶病变2例，双叶病变7例。肝切除(LR)3例(单叶2例，双叶1例)，肝移植(LT)6例。结果：术后无1例死亡。在平均117个月的随访期中，4名患者出现了肝内和/或肝外复发。1例切除的患者(胆叶范围)出现肝内复发，行二次肝移植治疗。9例患者中有7例(肝移植后2例，肝移植后存活)无病存活。结论：根据肝内病变程度量身定做肝内胆管病变时，外科治疗高肝性肝病有较好的远期疗效，而肝内胆管病变患者应严格限制肝内胆管病变的手术治疗。J外科医生奥科尔。2008：98：432-437。(C)2008年Wiley-Liss，Inc.
Background and Objectives: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare vascular neoplasm of the liver. Its therapeutic management remains difficult to define in curative intent. The aim of this study was to report long-term results of surgically managed patients.Methods: From 1990 to 2006, nine patients (25-64 years) were retrospectively enrolled in this study. Intrahepatic disease extent was monolobar and bilobar in two and seven patients, respectively. As primary treatment, liver resection (LR) and liver transplantation (LT) were performed in three (two monolobar and one bilobar extent) and six patients, respectively.Results: Postoperative mortality was nil. During a median follow-up Of 117 months, four patients developed intrahepatic and/or extrahepatic recurrence. One resected patient (with bilobar extent) presented with intrahepatic recurrence was secondary treated by LT. At the time of the follow-up, seven Out of the nine patients treated (two after LR, and live after LT) were alive and disease-free.Conclusions: Surgical treatment offers good long-term results in patients suffering from HEHE when LR is tailored to the intrahepatic disease extent: LT has to be considered in patients with bilobar intrahepatic disease whereas LR should be strictly limited to patients presenting with localized and monolobar intrahepatic disease. J Surg. Oncol. 2008:98:432-437. (c) 2008 Wiley-Liss, Inc.