Hedgehog-Like Gold-Coated Magnetic Microspheres that Strongly Inhibit Tumor Growth through Magnetomechanical Force and Photothermal Effects
Hedgehog-Like Gold-Coated Magnetic Microspheres that Strongly Inhibit Tumor Growth through Magnetomechanical Force and Photothermal Effects
复制标题
刺猬状金包磁性微球通过磁机械力和光热效应强烈抑制肿瘤生长
DOI：
10.1002/smll.201802799
复制
发表时间：
2018-11-08
期刊：
影响因子：
13.3
通讯作者：
Chu, Maoquan
中科院分区：
文献类型：
--
作者：
Chen, Yang;Han, Pomchol;Chu, Maoquan
利用磁力杀伤癌细胞的研究近年来受到了广泛的关注。本研究提出了一种新型的刺猬状微球组成的针状磁性纳米粒子与碳和金双壳。利用一种新型的低频振动磁场（VMF），这些具有尖锐表面的微球可以通过机械力严重破坏癌细胞并强烈抑制小鼠肿瘤生长。细胞杀伤效率取决于VMF暴露时间、频率、强度和微球浓度。一个微球在VMF下作用于癌细胞产生的最大机械力约为35.79 pN。在近红外激光照射下，微球也会引起光热烧蚀。机械力和光热消融协同刺激治疗后，小鼠肿瘤无法检测到。这些结果揭示了一个简单而高效的策略，使用磁性微球的局部治疗实体肿瘤的远程和非侵入性的方式。
Using magnetomechanical force to kill cancer cells has attracted great attention recently. This study presents novel hedgehog-like microspheres composed of needle-like magnetic nanoparticles with carbon and gold double shells. Using a novel low-frequency vibrating magnetic field (VMF), these microspheres with sharp surfaces can seriously damage cancer cells and strongly inhibit mouse tumor growth through mechanical force. The cell killing efficiency depends on VMF exposure time, frequency, strength, and microsphere concentration. The maximum mechanical force generated by one microsphere acting on a cancer cell under a VMF is about 35.79 pN. The microspheres also induce photothermal ablation after being triggered by near-infrared laser irradiation. Mouse tumors could not be detected after treatment with the synergistic stimuli of mechanical force and photothermal ablation. These results reveal a simple and highly efficient strategy using magnetic microspheres for local treatment of solid tumors in a remote and noninvasive manner.