Targeting Accuracy of Image-Guided Radiosurgery for Intracranial Lesions: A Comparison Across Multiple Linear Accelerator Platforms
Targeting Accuracy of Image-Guided Radiosurgery for Intracranial Lesions: A Comparison Across Multiple Linear Accelerator Platforms
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DOI：
10.1177/1533034615574385
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发表时间：
2016-04-01
影响因子：
2.8
通讯作者：
Wen, Ning
中科院分区：
文献类型：
--
作者：
Huang, Yimei;Zhao, Bo;Wen, Ning
目的：评价多个直线加速器平台上图像引导颅内放射外科手术的总体定位准确性。方法：在BrainLAB U形框架掩模中采集拟人头部体模的计算机断层扫描（切片厚度为1.0 mm）。体模嵌入三个5 mm直径的钨球轴承，模拟中央、左侧和前颅病变。在ExacTrac X射线或锥形束计算机断层扫描图像引导下，在3个Linac上将滚珠轴承定位到辐射等中心：（1）Novalis Tx上的ExacTrac X射线定位;（2）Novalis Tx上的锥形束计算机断层扫描定位;（3）TrueBeam上的锥形束计算机断层扫描定位;和（4）Edge上的锥形束计算机断层扫描定位。在3台直线加速器上进行4次图像引导程序后，将每个滚珠轴承定位到辐射等中心点5次，具有不同的初始设置误差，并比较残差的平均值（mu）和一个标准差（sigma）。结果如下：平均总体3个滚珠轴承位置，剩余设置误差的矢量长度（mm）Novalis Tx上ExacTrac X射线定位、Novalis Tx上锥形束计算机断层扫描定位的（mu +/- sigma）分别为0.6 +/- 0.2、1.0 +/- 0.5、0.2 +/- 0.1和0.3 +/- 0.1，TrueBeam上的锥形束计算机断层摄影定位和Edge上的锥形束计算机断层摄影定位，它们的范围（mm）分别为0.4至1.1、0.4至1.9、0.1至0.5和0.2至0.6。4个系统的成像和辐射等中心（mm）之间的一致性分别为0.6 +/- 0.1、0.7 +/- 0.1、0.3 +/- 0.1和0.2 +/- 0.1。结论：通过图像引导颅内立体定向放射外科治疗，可以达到与基于框架的立体定向放射外科相当的靶向准确性。
Purpose: To evaluate the overall positioning accuracy of image-guided intracranial radiosurgery across multiple linear accelerator platforms. Methods: A computed tomography scan with a slice thickness of 1.0 mm was acquired of an anthropomorphic head phantom in a BrainLAB U-frame mask. The phantom was embedded with three 5-mm diameter tungsten ball bearings, simulating a central, a left, and an anterior cranial lesion. The ball bearings were positioned to radiation isocenter under ExacTrac X-ray or cone-beam computed tomography image guidance on 3 Linacs: (1) ExacTrac X-ray localization on a Novalis Tx; (2) cone-beam computed tomography localization on the Novalis Tx; (3) cone-beam computed tomography localization on a TrueBeam; and (4) cone-beam computed tomography localization on an Edge. Each ball bearing was positioned 5 times to the radiation isocenter with different initial setup error following the 4 image guidance procedures on the 3 Linacs, and the mean (mu) and one standard deviation (sigma) of the residual error were compared. Results: Averaged overall 3 ball bearing locations, the vector length of the residual setup error in mm (mu +/- sigma) was 0.6 +/- 0.2, 1.0 +/- 0.5, 0.2 +/- 0.1, and 0.3 +/- 0.1 on ExacTrac X-ray localization on a Novalis Tx, cone-beam computed tomography localization on the Novalis Tx, cone-beam computed tomography localization on a TrueBeam, and cone-beam computed tomography localization on an Edge, with their range in mm being 0.4 to 1.1, 0.4 to 1.9, 0.1 to 0.5, and 0.2 to 0.6, respectively. The congruence between imaging and radiation isocenters in mm was 0.6 +/- 0.1, 0.7 +/- 0.1, 0.3 +/- 0.1, and 0.2 +/- 0.1, for the 4 systems, respectively. Conclusions: Targeting accuracy comparable to frame-based stereotactic radiosurgery can be achieved with image-guided intracranial stereotactic radiosurgery treatment.