Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study.
Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study.
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DOI：
10.1016/j.envint.2018.07.016
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发表时间：
2018-10
影响因子：
11.8
通讯作者：
Bo-yi Yang;M. Bloom;I. Markevych;Z. Qian;M. Vaughn;L. Cummings-Vaughn;Shanshan Li;Gongbo Chen
中科院分区：
文献类型：
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作者：
Bo-yi Yang;M. Bloom;I. Markevych;Z. Qian;M. Vaughn;L. Cummings-Vaughn;Shanshan Li;Gongbo Chen
背景关于空气污染对血脂的影响的信息很少，特别是在发展中国家。本研究旨在探讨长期接触环境空气污染物与血脂水平及血脂异常的关系。方法2009年，在东北3个城市中国进行的33个社区中国人健康调查中，共招募了15,477名年龄在18~74 之间的调查对象。测定受试者血液样本中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)和低密度脂蛋白胆固醇(LDLC)。利用33个社区(使用空间统计模型预测了直径为≤1.0 μm(PM1)和≤2.5 μm(PM2.5)的颗粒物)或11个空气监测站(直径为≤10 μm(PM10)、二氧化硫(SO2)、二氧化氮(NO2)和臭氧(O3)的颗粒物)的数据，评估了3年(2006年至2008年)的平均空气污染浓度。结果我们发现暴露于空气污染物(尤其是PM1和PM2.5)与血脂水平之间存在许多显著的相关性。大多数关联表明对血脂标记物的有害影响(例如，PM1增加10 μg/m~3分别与TC、TG和−-C水平升高1.6%(95%可信区间：1.1、2.0)、2.9%(95%可信区间：LDL3.3、9.3)和3.2%(95%可信区间：2.6、3.9)相关，但1.4%(95%可信区间：−1.8，较低的高密度脂蛋白胆固醇水平)，尽管发现了与−有益的联系。在对血脂异常的分析中，所有观察到的关联都表明空气污染物对血脂的有害影响，而没有观察到与臭氧有显著的有益关联。分层分析显示，在超重或肥胖的参与者中，这种关联更强；性别和年龄改变了这种关联，但影响的模式是混合的。结论长期的环境空气污染与血脂变化和血脂紊乱有关，特别是在超重或肥胖的参与者中。
BackgroundLittle information exists on the lipidemic effects of air pollution, particularly in developing countries. We aimed to investigate the associations of long-term exposure to ambient air pollutants with lipid levels and dyslipidemias in China.MethodsIn 2009, a total of 15,477 participants aged 18–74 years were recruited from the 33 Communities Chinese Health Study conducted in three Northeastern China cities. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured in participants' blood specimens. Three year (2006–08) average air pollution concentrations were assessed using data from 33 communities (particles with diameters ≤1.0 μm (PM1) and ≤2.5 μm (PM2.5) were predicted using a spatial statistical model) or 11 air monitoring stations (particles with diameters ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3)). Associations were evaluated by two-level logistic and generalized linear regression models.ResultsWe detected many significant associations between exposure to air pollutants (especially for PM1and PM2.5) and blood lipid levels. Most of the associations suggested deleterious effects on blood lipid markers (e.g., a 10 μg/m3increase in PM1was associated with 1.6% (95% confidence interval (CI): 1.1, 2.0), 2.9% (95% CI: −3.3, 9.3), and 3.2% (95% CI: 2.6, 3.9) higher levels of TC, TG, and LDL-C, respectively, but 1.4% (95% CI: −1.8, −0.9) lower HDL-C levels), although beneficial associations were found for O3. In analysis with dyslipidemias, all the observed associations suggested deleterious lipidemic effects of air pollutants, and no significant beneficial association was observed for O3. Stratified analyses showed that the associations were stronger in overweight or obese participants; sex and age modified the associations, but the pattern of effects was mixed.ConclusionsLong-term ambient air pollution was associated with both altered lipid profiles and dyslipidemias, especially among overweight or obese participants.