Levodopa therapy improves motor function in HIV-infected children with extrapyramidal syndromes
Levodopa therapy improves motor function in HIV-infected children with extrapyramidal syndromes
复制标题
DOI：
10.1212/wnl.47.6.1583
复制
发表时间：
1996-12-01
期刊：
影响因子：
9.9
通讯作者：
Oleske, J
中科院分区：
文献类型：
--
作者：
Mintz, M;Tardieu, M;Oleske, J
5名4 - 13岁的人类免疫缺陷病毒1型（HIV-1）感染儿童表现出锥体外系功能障碍，其特征为僵硬/僵硬、步态不稳/拖曳步态、构音障碍/流涎/吞咽功能障碍、拟态减退/无表达面容和运动迟缓。左旋多巴治疗使所有症状得到初步改善，并且大多数患者的效果持续存在。左旋多巴是一种有效的治疗HIV-1感染儿童锥体外系综合征的药物，可增强运动功能，改善生活质量。
Five children with human immunodeficiency virus type-1 (HIV-1) infection, aged 4 to 13 years, manifested extrapyramidal dysfunction characterized by rigidity/stiffness, ambulation difficulties/shuffling gait, dysarthria/drooling/swallowing dysfunction, hypomimetic/inexpressive facies, and bradykinesia. Levodopa therapy caused an initial improvement in all symptoms, and the effect was sustained in most patients. Levodopa is a useful adjunctive therapy in HIV-1-infected children with extrapyramidal syndromes, by enhancing motor function and improving their quality of life.