Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei
Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei
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DOI：
10.1016/j.jchemneu.2008.07.009
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发表时间：
2008-12-01
影响因子：
2.8
通讯作者：
Herman, James P.
中科院分区：
文献类型：
--
作者：
Tauchi, Miyuki;Zhang, Rong;Herman, James P.
胰高血糖素样肽-1 （Glucagon-like peptide-1, GLP-1）参与调节神经内分泌和自主神经功能。下丘脑室旁核（PVN）含有GLP-1纤维聚集并表达GLP-1受体，可能是GLP-1信号传导的作用位点。目前的研究旨在确定GLP-1的作用域，重点关注PVN中不同神经内分泌和自主神经细胞群的轴体作用。这些数据表明，在内侧副细胞PVN中，促肾上腺皮质激素释放激素神经元上存在丰富的glp -1免疫反应性末端附着。GLP-1阳性钮扣也可以在催产素能神经元和向孤立束核区域投射的逆行标记的自主神经前神经元上观察到。相比之下，GLP-1表达的抗利尿激素能神经元非常少。总的来说，数据表明中枢GLP-1系统优先作用于PVN垂体营养下带的神经元，这与GLP-1对促肾上腺皮质激素释放的兴奋作用一致。GLP-1也可能影响催产素的分泌并控制脑干心血管接力的流出。(C) 2008 Elsevier B.V.版权所有
Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled preautonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays. (C) 2008 Elsevier B.V. All rights reserved.