Further Morphologic Studies on Collagen Injected into Canine Vocal Folds
Further Morphologic Studies on Collagen Injected into Canine Vocal Folds
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犬声带注射胶原蛋白的进一步形态学研究
DOI：
10.1177/000348949110001209
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
E. Marbaix
中科院分区：
文献类型：
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作者：
M. Remacle;E. Marbaix
我们比较了注射到犬声带中的三种类型的可溶性牛胶原的形态学结局：1）含有35 mg/mL胶原的Zyderm胶原植入物（ZCI I），2）含有65 mg/mL胶原的Zyderm胶原植入物（ZCI II），和3）含有35 mg/mL胶原的GAX胶原（用0.0075%戊二醛进行最低限度交联）。光学和电子显微镜显示良好的宿主耐受性和长期持久性的三种类型的胶原蛋白在注射部位。胶原植入物逐渐被成纤维细胞和毛细血管定植，伴随着宿主胶原沉积。与注射Teflon的典型宿主反应相反，未发生炎症过程或异物反应。GAX胶原的定殖比ZCI I和ZCI II慢。三种类型的可注射胶原之间没有其他显著差异。所有这三种材料似乎都非常适合用于喉植入物;此外，它们似乎最符合良好植入物的公认要求：它们易于注射，耐受性良好，并且可以持续很长时间。我们更喜欢GAX胶原蛋白用于临床，因为它的反应性较低，稳定性较高，而且不需要过度注射（GAX收缩小于ZCI I和ZCI II）。
We compared the morphologic fate of three types of soluble bovine collagen injected into vocal folds of dogs: 1) Zyderm collagen implant containing 35 mg/mL of collagen (ZCI I), 2) Zyderm collagen implant containing 65 mg/mL of collagen (ZCI II), and 3) GAX collagen containing 35 mg/mL of collagen minimally cross-linked with 0.0075% glutaraldehyde. Light and electron microscopy showed good host tolerance and a long-term persistence of the three types of collagen at the site of injection. The collagen implants were progressively colonized by fibroblasts and capillaries accompanied by host collagen deposition. No inflammatory process or foreign body reaction occurred, in contrast to the typical host reaction to injected Teflon. The colonization of GAX collagen was slower than for ZCI I and ZCI II. No other significant difference was evident among the three types of injectable collagen. All three appear to be very suitable materials for laryngeal implants; moreover, they seem to best meet accepted requirements for a good implant: they are easy to inject, they are well tolerated, and they persist for a long time. We prefer GAX collagen for clinical use because of its lower reactivity and higher stability, and because overinjection is not necessary (GAX shrinks less than ZCI I and ZCI II).