Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: Final report of the Veterans Affairs randomized trial
Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: Final report of the Veterans Affairs randomized trial
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DOI：
10.1016/s0735-1097(00)00834-2
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发表时间：
2000-10-01
影响因子：
24
通讯作者：
Rahimtoola, SH
中科院分区：
文献类型：
--
作者：
Hammermeister, K;Sethi, GK;Rahimtoola, SH
本研究的目的是比较生物人工心脏瓣膜和机械心脏瓣膜的长期生存率和瓣膜相关并发症。不同的心脏瓣膜可能有不同的患者预后。方法：在13个VA医疗中心接受单个主动脉瓣置换术（AVR）或二尖瓣置换术（MVR）的575例患者随机接受生物假体或机械瓣膜置换术。结果：通过15年的生存分析，机械瓣膜与生物假体相比，AVR术后的全因死亡率较低（66%对79%，p = 0.02），而MVR术后的全因死亡率较低。原发性瓣膜衰竭主要发生在患者中
OBJECTIVES The goal of this study was to compare long-term survival and valve-related complications between bioprosthetic and mechanical heart valves.BACKGROUND Different heart valves may have different patient outcomes.METHODS Five hundred seventy-five patients undergoing single aortic valve replacement (AVR) or mitral valve replacement (MVR) at 13 VA medical centers were randomized to receive a bioprosthetic or mechanical valve.RESULTS By survival analysis at 15 years, all cause mortality after AVR was lower with the mechanical valve versus bioprosthesis (66% vs. 79%, p = 0.02) but not after MVR. Primary valve failure occurred mainly in patients