Immunovirological Correlates in Human Rabies Treated With Therapeutic Coma
Immunovirological Correlates in Human Rabies Treated With Therapeutic Coma
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DOI：
10.1002/jmv.21785
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发表时间：
2010-07-01
影响因子：
12.7
通讯作者：
Fooks, A. R.
中科院分区：
文献类型：
--
作者：
Hunter, M.;Johnson, N.;Fooks, A. R.
一名37岁的女性入院，在接下来的5天内发展为进行性脑炎。使用狂犬病TaqMan（C）PCR分析的颈部皮肤活检证实了狂犬病病毒RNA。她在南非时有狂犬病暴露史，但未接受暴露前或暴露后预防。根据“密尔沃基方案”，对她进行了治疗性昏迷治疗，但未能阻止患者死亡。从CSF和唾液中分离出狂犬病病毒，并在血清（从第11天开始）和脑脊液（从第13天开始）中显示狂犬病抗体。她在住院第35天死亡。尸检标本显示中枢神经系统中存在狂犬病抗原、病毒RNA和活狂犬病病毒。J. Med. Virol. 82：1255- 1265，2010。(C)2010 Wiley-Liss，Inc.
A 37-year-old woman was admitted to hospital and over the next 5 days developed a progressive encephalitis. Nuchal skin biopsy, analyzed using a Rabies TaqMan(C) PCR, demonstrated rabies virus RNA. She had a history in keeping with exposure to rabies whilst in South Africa, but had not received pre- or post-exposure prophylaxis. She was treated with a therapeutic coma according to the "Milwaukee protocol," which failed to prevent the death of the patient. Rabies virus was isolated from CSF and saliva, and rabies antibody was demonstrated in serum (from day 11 onwards) and cerebrospinal fluid (day 13 onwards). She died on day-35 of hospitalization. Autopsy specimens demonstrated the presence of rabies antigen, viral RNA, and viable rabies virus in the central nervous system. J. Med. Virol. 82:1255-1265,2010. (C) 2010 Wiley-Liss, Inc.