Determination of left ventricular mass by computed tomography.
Determination of left ventricular mass by computed tomography.
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通过计算机断层扫描测定左心室质量。
DOI：
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发表时间：
1980
影响因子：
2.8
通讯作者：
T. Hayashi
中科院分区：
文献类型：
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作者：
C. G. Skiöldebrand;M. Lipton;C. Mavroudis;T. Hayashi
摘要探讨了计算机断层扫描测量活体左心室质量的能力，并与死后测量值进行了比较。研究组包括22只体重在9 - 28 kg之间的犬，其中包括5只左心室肥大犬。在稳态灌注造影剂期间，获得了从心尖到基底的连续非增强计算机断层扫描。在每一个1 cm厚的计算机断层扫描上代表左心室心肌的图像元素（像素）的总数以两种方式确定：用计算机技术和手动跟踪方法。左心室质量计算为心肌总体积（由像素确定）和犬心肌比重的乘积。用两种计算机断层扫描方法获得的结果与尸检时测量的左心室质量相关（计算机方法，相关系数[r] = 0.95;估计值的标准误差[SEE] = 8.10 g，示踪法，r = 0.95; SEE = 8.38 g）。这些体内测量结果是可重复的，并且似乎不受左心室肥大的显著影响。通过在尸检时对8只动物原位心脏进行重新扫描，评估心脏运动对测量结果的影响。这些结果显示，由于尸检时计算机断层扫描值的估计标准误差的运动，导致适度（两倍）增加。已知邻近低密度肺组织引起的伪影是计算机断层扫描测量中的误差来源。通过在水模中扫描切除的心脏来检查，发现这对结果没有显著影响。这一可行性研究代表了计算机断层扫描在心脏病诊断中的应用和验证的一个逻辑步骤。将这些结果外推到人类受试者必须谨慎，但似乎没有主要的技术原因，为什么这种使用计算机断层扫描不能乐观地追求。
Abstract The capability of computed tomographic scanning to provide measurements of left ventricular mass in vivo was explored and compared with postmortem values. The study group comprised 22 dogs weighing between 9 and 28 kg and included 5 dogs with left ventricular hypertrophy. Serial nongated computed tomographic scans from the cardiac apex to base were obtained during steady state infusion of contrast medium. The total number of picture elements (pixels) representing the left ventricular myocardium on each 1 cm thick computed tomographic scan was determined in two ways: with a computer technique and with a manual tracing method. Left ventricular mass was calculated as the product of total myocardial volume (determined by pixels) and the specific gravity of canine myocardium. The results obtained with both computed tomographic methods correlated with the left ventricular mass measured at autopsy (computer method, correlation coefficient [r] = 0.95; standard error of the estimate [SEE] = 8.10 g and for the tracing method, r = 0.95; SEE = 8.38 g). These in vivo measurements were reproducible and appeared not to be significantly affected by left ventricular hypertrophy. The effect of cardiac motion on the measurements was assessed by rescanning eight animals at postmortem examination with the heart in situ. These results showed a modest (twofold) increase due to motion in the standard error of the estimate over the computed tomographic value at autopsy. Artifact due to adjacent lung tissue with low density is known to be a source of error in computed tomographic measurements. This was examined by scanning the excised hearts in a water phantom and was found not to significantly influence the results. This feasibility study represents a logical step in the application and validation of computed tomography in diagnosing heart disease. The extrapolation of these results to human subjects must be made cautiously, but there appear to be no major technical reasons why this use of computed tomography cannot be optimistically pursued.