Determination of 61 elements in urine samples collected from a non-occupationally exposed UK adult population
Determination of 61 elements in urine samples collected from a non-occupationally exposed UK adult population
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DOI：
10.1016/j.toxlet.2014.08.019
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发表时间：
2014-12-01
影响因子：
3.5
通讯作者：
Cocker, John
中科院分区：
文献类型：
--
作者：
Morton, Jackie;Tan, Emma;Cocker, John
背景：61种元素的水平是从132名职业未暴露的英国成年人的尿样中确定的。在这项研究中，所有元素的电感耦合等离子体质谱法测定，但方法是'定制'的元素，在总共六个分析方法进行。在英国人群中首次报告了19种元素的第95百分位值，这些元素没有可用的比较。从一些个体中收集重复尿样，并对数据进行混合效应建模，以估计个体间和同一个体内的变异。对61种元素中的31种进行了混合效应建模，其中超过三分之二的数据高于LOQ，并报告了个体之间和个体内的变异。分析发现，分析物浓度的肌酸酐调整被发现对31种元素中的22种有益，并且发现吸烟者比非吸烟者表现出显着更高的镉但更低的硼。对于大多数元素，数据与其他已发表的数据相比，但在本研究中观察到尿铅、铬、钒和钨的浓度较高。(C)2014作者出版社：Elsevier爱尔兰Ltd.
Background: levels for 61 elements were established in urine samples collected from 132 occupationally unexposed UK adults. In this study all elements were determined by inductively coupled plasma-mass spectrometry, but methods were 'tailored' to the elements; in total six analytical methods were undertaken. For the first time in a UK population 95th percentile values are reported for 19 elements for which there is no available comparison. Repeat urine samples were collected from some individuals and mixed effects modelling was carried out on the data to give an estimation of variation both between individuals and within the same individual. The mixed effects modelling was undertaken on 31 of the 61 elements for which there were more than two thirds of data above the LOQ and variations of between and within individuals are reported. The analysis found that creatinine adjustment of analyte concentrations was found to be beneficial for 22 of the 31 elements and that smokers were found to exhibit significantly higher cadmium but lower boron than non-smokers. For most elements, the data compare well with other published data but higher concentrations were observed in this study for urinary lead, chromium, vanadium and tungsten. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.