Thermodynamic influences on C-H bond oxidation
Thermodynamic influences on C-H bond oxidation
复制标题
DOI：
10.1142/9781848160699_0001
复制
发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Mayer, JM
中科院分区：
文献类型：
--
作者：
Mayer, JM
有机分子的选择性部分氧化在化学和生物学中是重要的，并且具有实质性的商业意义。广泛的生化系统在温和的条件下完成这种转化，并具有高选择性，如本卷所讨论的。这些系统为发现化学氧化系统（称为仿生系统）提供了路标。下面的章节研究了不同种类的反应和不同种类的氧化还原酶。本章的目标是为这些植根于热化学的各种反应提供一个框架。我们开始与热化学的整体转变，例如甲烷到甲醇，然后转移到讨论机制和热力学的个别反应步骤。一个关键问题是反应步骤的动力学如何受到其热力学驱动力的影响。主要重点将放在涉及氢原子转移的反应上。
Selective partial oxidations of organic molecules are important in chemis try and biology, and are of substantial commercial significance. A wide range of biochemical systems accomplish such transformations under mild conditions and with high selectivity, as discussed throughout this volume. These systems provide guideposts for the discovery of chemical oxidation systems, termed biomimetic systems. The following chapters examine dif ferent classes of reactions and different groups of redox enzymes. The goal of this chapter is to provide a framework for these various reactions rooted in their thermochemistry. We begin with the thermochemistry of the overall transformations, for instance methane to methanol, then move to discus sions of mechanisms and the thermodynamics of individual reaction steps. A key issue is how the kinetics of a reaction step are affected by its thermodynamic driving force. The primary focus will be on reactions that involve transfer of a hydrogen atom.