In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex
In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex
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新型二氢叶酸还原酶抑制剂 PS-15 及其循环代谢物对抗鸟分枝杆菌复合体的体外活性
DOI：
10.1128/aac.39.8.1862
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发表时间：
1995
影响因子：
4.9
通讯作者：
M. Cynamon
中科院分区：
文献类型：
--
作者：
S. C. Meyer;S. Majumder;M. Cynamon
PS-15（一种新型二氢叶酸还原酶抑制剂）及其循环代谢物针对 31 种临床鸟分枝杆菌复合菌株的体外活性进行了评估。 PS-15 的肉汤稀释 MIC 范围为 16 至 64 微克/毫升。环状代谢物的活性是母体化合物的三到五倍。在鸟分枝杆菌感染的小鼠测试系统中进一步评估这些化合物将引起人们的兴趣。
PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite were evaluated for in vitro activity against 31 clinical Mycobacterium avium complex isolates. Broth dilution MICs of PS-15 ranged from 16 to 64 micrograms/ml. The cyclic metabolite was three to five times more active than the parent compound. Further evaluation of these compounds in an M. avium-infected murine test system will be of interest.
DOI：
10.1016/s0891-5520(05)70140-9
发表时间：
2000
期刊：
Infectious disease clinics of North America.
影响因子：
--
作者：
Tantisiriwat,W;Powderly,WG
通讯作者：
Powderly,WG