Increase in the Incidence of Type 1 Diabetes Mellitus in Children in Three Cities in Poland, 1987-1999
Increase in the Incidence of Type 1 Diabetes Mellitus in Children in Three Cities in Poland, 1987-1999
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1987-1999 年波兰三个城市儿童 1 型糖尿病发病率的增加
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Z. Szybinski
中科院分区：
文献类型：
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作者：
H. Dziatkowiak;M. Ciechanowska;R. Wasikowa;A. Symonides;J. Bieniasz;H. Trippenbach;L. Korniszewski;Z. Szybinski
这项研究的目的是评估波兰三个城市1987年至1999年间0-14岁儿童1型糖尿病(DM)发病率的趋势。研究区域包括克拉科夫省和弗罗茨瓦夫省以及华沙市。这些数据是在1997年之前的EURODIAB研究框架内，然后在卫生部的项目范围内，根据登记册前瞻性地收集的。在13年的研究期间，766名儿童(380名女孩，386名男孩)被确诊为新诊断的1型糖尿病。总体年龄标化发病率克拉科夫省为8.4/10万标准化人口/年(95%可信区间7.4~9.3)，弗罗茨瓦夫省为6.5/10万/年(95%可信区间5.6~7.4)，华沙为7.9/10万/年(95%可信区间6.9~8.8)。在这三个城市，0-14岁的儿童有明显的增长趋势。对年龄分组趋势的分析表明，华沙和克拉科夫省所有三个年龄组的发病率都有显著增加(克拉科夫省0.001至4岁儿童，华沙0.05；5至9岁儿童，0.05；华沙10至14岁，0.05，华沙0.005)。在弗罗茨瓦夫省，观察到0-4岁儿童(P<；0.001)和5-9岁儿童(P<；005)的儿童显著增加。在10-14岁的儿童中，这一增长在统计上并不显着。我们的研究结果表明，儿童1型糖尿病的发病率正在上升。类似的现象也在许多其他国家发生。在克拉科夫省和弗罗茨瓦夫省的5-9岁儿童和华沙的10-14岁儿童中，发病率增加幅度最大。自1996年以来观察到的发病率超过每年9.0/100000，使波兰跻身于低至中等发病率国家之列。
The aim of this study was to evaluate the trends in the incidence of type 1 diabetes mellitus (DM) in children aged 0-14 years between 1987 and 1999 in three cities in Poland. The study area comprised the provinces of Cracow and Wroclaw and the city of Warsaw. The data were collected prospectively on the basis of the register within the framework of the EURODIAB study up till 1997 and then within the project of the Ministry of Health. During the 13 years of the study period, 766 children (380 girls, 386 boys) with newly diagnosed type 1 DM were identified. The overall age-standardized incidence rates were 8.4/100,000 standardized population/year (95% CI 7.4-9.3) for Cracow province, 6.5/100,000/year (95% CI 5.6-7.4) for Wroclaw province and 7.9/100,000/year (95% CI 6.9-8.8) for Warsaw. A significant trend of increase for children aged 0-14 years was found in the three cities. The analysis of the trend in age subgroups showed a significant increase in incidence in all three age subgroups in Warsaw and Cracow province (0-4 year-old children, p <0.05; 5-9 year-olds, p <0.001 in Cracow province, p <0.05 in Warsaw, and in 10-14 year-olds, p <0.05 in Cracow province, p <0.005 in Warsaw). In the Wroclaw province a significant increase was observed in children aged 0-4 years (p <0.05) and 5-9 years (p <0.001). In children aged 10-14 years the increase was not statistically significant. The results of our study showed that the incidence of type 1 DM in children is rising. A similar phenomenon is occurring in many other countries. The greatest increase of incidence was observed in the 5-9 year-old subgroup of children in Cracow and Wroclaw provinces and in children aged 10-14 years in Warsaw. The incidence rates in excess of 9.0/100,000 per year observed since 1996 have placed Poland in the group of countries with low to medium incidence.
DOI：
10.1210/jcem.85.2.6406-1
发表时间：
2000
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
Rosenbloom,AL;Schatz,DA;Krischer,JP;Skyler,JS;Becker,DJ;Laporte,RE;Libman,I;Pietropaolo,M;Dosch,HM;Finberg,L;Muir,A;Tamborlane,WV;Grey,M;Silverstein,JH;Malone,JI
通讯作者：
Malone,JI