Pervasive developmental disorders in preschool children: Confirmation of high prevalence
Pervasive developmental disorders in preschool children: Confirmation of high prevalence
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DOI：
10.1176/appi.ajp.162.6.1133
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发表时间：
2005-06-01
影响因子：
17.7
通讯作者：
Fombonne, E
中科院分区：
文献类型：
--
作者：
Chakrabarti, S;Fombonne, E
目的：据报道，广泛性发育障碍的发病率有所上升，作者在之前对美国斯塔福德学龄前儿童的研究中发现，这一比例为每10,000人中有62.6人。K.他们在2002年进行了另一项调查，以估计在晚出生队列的儿童中的患病率，并将其与同一地区以前的调查结果进行比较。方法：对10,903名年龄在4.0至6.0岁之间的儿童进行发育问题筛查，这些儿童在调查日期居住在中部城镇。一个多学科的团队使用标准化的诊断访谈，心理测试，和医疗workups.Results：64名儿童（85.9%的男孩）被诊断为广泛性发育障碍的症状暗示儿童进行了密集的评估。所有广泛性发育障碍的患病率为58.7/10，000，95%置信区间（CI）为45.2-74.9，自闭症为22.0/10，000（95% CI = 14.1-32.7），其他变异为36.7/10，000（95% CI = 26.2-49.9）。这些比率与以前的比率没有显著差异。诊断时的平均年龄为37.8个月，53.1%的儿童最初是由健康访问者转介的。在64名患有广泛性发育障碍的儿童中，29.8%患有精神发育迟滞，但这一比率因疾病亚型而异。少数儿童有相关的医疗conditions.Conclusions：广泛性发育障碍的发病率高于15年前的报道。本研究中的发病率与来自同一地区并采用相同方法调查的先前出生队列的发病率相当，表明发病率稳定。
Objective: The rate of reported pervasive developmental disorders has increased, and the authors found a rate of 62.6 per 10,000 in a previous study of preschoolers in Stafford, U. K. They conducted another survey in 2002 to estimate the prevalence in children in a later birth cohort and to compare it to previous findings from the same area.Method: Screening for developmental problems included 10,903 children ages 4.0 to 6.0 years who were living in a Midlands town on the survey date. Children with symptoms suggestive of pervasive developmental disorders were intensively assessed by a multidisciplinary team using standardized diagnostic interviews, psychometric tests, and medical workups.Results: Sixty-four children (85.9% boys) were diagnosed with pervasive developmental disorders. The prevalence was 58.7 per 10,000, with a 95% confidence interval (CI) of 45.2-74.9, for all pervasive developmental disorders, 22.0 per 10,000 (95% CI = 14.1-32.7) for autistic disorder, and 36.7 per 10,000 (95% CI = 26.2-49.9) for other variants. These rates were not significantly different from the previous rates. The mean age at diagnosis was 37.8 months, and 53.1% of the children were originally referred by health visitors. Of the 64 children with pervasive developmental disorders, 29.8% had mental retardation, but this rate varied by disorder subtype. Few children had associated medical conditions.Conclusions: The rate of pervasive developmental disorders is higher than reported 15 years ago. The rate in this study is comparable to that in previous birth cohorts from the same area and surveyed with the same methods, suggesting a stable incidence.