Central Nervous System Involvement of Rhabdomyosarcoma: A Single Institution Experience.
Central Nervous System Involvement of Rhabdomyosarcoma: A Single Institution Experience.
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横纹肌肉瘤的中枢神经系统参与：一种机构的经验。
DOI：
10.1097/mph.0000000000001166
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发表时间：
2019-03
期刊：
影响因子：
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通讯作者：
Garrington TP
中科院分区：
文献类型：
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作者：
Moreira DC;Macy ME;Cost CR;Greffe BS;Garrington TP
横纹肌肉瘤累及中枢神经系统的发生率低，预后差。我们提出了一项关于儿童横纹肌肉瘤累及中枢神经系统的单一机构分析。在59例患者中，CNS受累的患病率为11.9%（7例患者），高于既往报告。在6例死于疾病的患者中，所有人都有快速进展，中位生存期为14天。较高的发生率可能继发于治疗调整或更灵敏的检测。这些发现对中枢神经系统受累时的决策是有用的，并可能导致未来横纹肌肉瘤临床试验的修改。
The incidence of central nervous system (CNS) involvement in patients with rhabdomyosarcoma is low, and the outcome is dismal. We present a single institution analysis of CNS involvement of pediatric rhabdomyosarcoma. In 59 patients, the prevalence of CNS involvement was 11.9% (seven patients), higher than prior reports. Of the six deaths from disease, all had rapid progression, with a median survival of 14 days. The higher incidence could be secondary to treatment modifications or more sensitive detection. These findings are useful for decisions at the time of CNS involvement and could lead to modifications for future rhabdomyosarcoma clinical trials.