Selective detection of cavitation bubbles by triplet pulse sequence in high-intensity focused ultrasound treatment
Selective detection of cavitation bubbles by triplet pulse sequence in high-intensity focused ultrasound treatment
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DOI：
10.7567/jjap.57.07lf12
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发表时间：
2018-06
影响因子：
1.5
通讯作者：
Ryosuke Iwasaki;Ryo Nagaoka;S. Yoshizawa;S. Umemura
中科院分区：
文献类型：
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作者：
Ryosuke Iwasaki;Ryo Nagaoka;S. Yoshizawa;S. Umemura
声空化气泡被认为可以增强高强度聚焦超声（HIFU）治疗中的加热效果。对空化气泡的高灵敏度和高选择性检测是预测空化效应的治疗效果和副作用，保证治疗的有效性和安全性的重要手段。脉冲反转（PI）技术通过增强回波信号的二次谐波分量而被广泛用于微泡成像。然而，它有困难的分离微气泡的非线性响应，由于非线性传播。在这项研究中，三重脉冲（3P）的方法进行了研究，专门图像空化气泡提取1.5分谐波分量。所提出的3P方法描绘的空化气泡的对比度显着高于那些在传统的成像方法与PI。结果表明，3P方法是有效的，具体检测微泡在空化增强HIFU治疗。
Acoustic cavitation bubbles are known to enhance the heating effect in high-intensity focused ultrasound (HIFU) treatment. The detection of cavitation bubbles with high sensitivity and selectivity is required to predict the therapeutic and side effects of cavitation, and ensure the efficacy and safety of the treatment. A pulse inversion (PI) technique has been widely used for imaging microbubbles through enhancing the second-harmonic component of echo signals. However, it has difficulty in separating the nonlinear response of microbubbles from that due to nonlinear propagation. In this study, a triplet pulse (3P) method was investigated to specifically image cavitation bubbles by extracting the 1.5th fractional harmonic component. The proposed 3P method depicted cavitation bubbles with a contrast ratio significantly higher than those in conventional imaging methods with and without PI. The results suggest that the 3P method is effective for specifically detecting microbubbles in cavitation-enhanced HIFU treatment.