Enlarged perivascular spaces are associated with cognitive function in healthy elderly men
Enlarged perivascular spaces are associated with cognitive function in healthy elderly men
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DOI：
10.1136/jnnp.2003.030858
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发表时间：
2004-11-01
影响因子：
11
通讯作者：
Deary, IJ
中科院分区：
文献类型：
--
作者：
MacLullich, AMJ;Wardlaw, JM;Deary, IJ
目的：磁共振成像（MRI）显示的白色病变增加与老年人认知功能恶化相关。扩大的血管周围间隙（EPVS）通常与WM病变共存并共享一些风险因素，但未在已发表的量表中进行量化。目前尚不清楚EPVS的程度是否也与认知功能有关。我们测试的假设，更多的EPVS将与更差的认知functions.Methods：97名健康男性（65-70岁），而不是药物，进行了MRI扫描和全面的认知测试。结果：在已发表的WM损伤评定量表上的得分高度显著和正相关（rho = 0.61至0.91，p < 0.01），
Objectives: Increased white matter (WM) lesions on magnetic resonance imaging (MRI) are associated with worse cognitive function in older people. Enlarged perivascular spaces (EPVS) commonly coexist with and share some risk factors for WM lesions but are not quantified in published scales. It is not known whether the extent of EPVS is also associated with cognitive function. We tested the hypothesis that more EPVS would be associated with worse cognitive function.Methods: Ninety seven healthy men (65-70 years), not on medications, underwent MRI scanning and comprehensive cognitive testing. EPVS were quantified in both the basal ganglia/centrum semiovale and the hippocampus, and WM lesions were measured.Results: Scores on published WM lesion rating scales intercorrelated highly significantly and positively (rho = 0.61 to 0.91, p