Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2.
Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2.
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DOI：
10.1111/j.1749-6632.2012.06522.x
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发表时间：
2012-06
影响因子：
5.2
通讯作者：
McCole DF
中科院分区：
文献类型：
--
作者：
McCole DF
蛋白酪氨酸磷酸酶非受体2型（PTPN2）已被确定为炎症性肠病（IBD）的候选基因。然而，PTPN2基因突变导致IBD发病的机制尚未明确。PTPN2作为促炎细胞因子干扰素 -γ（IFN -γ）诱导信号的负调节因子。已知IFN -γ不仅在克罗恩病（CD）的发病机制中起重要作用，还会增加肠上皮屏障的通透性。我们已经表明，PTPN2通过限制IFN -γ增加上皮通透性的能力以及防止诱导成孔蛋白克劳丁 - 2的表达来保护上皮屏障功能。这些数据确定了PTPN2作为肠上皮屏障保护者的重要功能作用，并为PTPN2突变如何导致CD的病理生理学变化提供了线索。
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) has been identified as an inflammatory bowel disease (IBD) candidate gene. However, the mechanism through which mutations in the PTPN2 gene contribute to the pathogenesis of IBD has not been identified. PTPN2 acts as a negative regulator of signaling induced by the proinflammatory cytokine, interferon-gamma (IFN-γ). IFN-γ is known not only to play an important role in the pathogenesis of Crohn’s disease (CD), but also to increase permeability of the intestinal epithelial barrier. We have shown that PTPN2 protects epithelial barrier function by restricting the capacity of IFN-γ to increase epithelial permeability and prevent induction of expression of the pore-forming protein, claudin-2. These data identify an important functional role for PTPN2 as a protector of the intestinal epithelial barrier and provide clues as to how PTPN2 mutations may contribute to the pathophysiology of CD.
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影响因子：
30.8
作者：
通讯作者：
--
影响因子：
29.4
作者：
Scharl M;Paul G;Weber A;Jung BC;Docherty MJ;Hausmann M;Rogler G;Barrett KE;McCole DF
通讯作者：
McCole DF
影响因子：
30.8
作者：
Fisher, Sheila A.;Tremelling, Mark;Anderson, Carl A.;Gwilliam, Rhian;Bumpstead, Suzannah;Prescott, Natalie J.;Nimmo, Elaine R.;Massey, Dunecan;Berzuini, Carlo;Johnson, Christopher;Barrett, Jeffrey C.;Cummings, Fraser R.;Drummond, Hazel;Lees, Charlie W.;Onnie, Clive M.;Hanson, Catherine E.;Blaszczyk, Katarzyna;Inouye, Mike;Ewels, Philip;Ravindrarajah, Radhi;Keniry, Andrew;Hunt, Sarah;Carter, Martyn;Watkins, Nick;Ouwehand, Willem;Lewis, Cathryn M.;Cardon, Lon;Lobo, Alan;Forbes, Alastair;Sanderson, Jeremy;Jewell, Derek P.;Mansfield, John C.;Deloukas, Panos;Mathew, Christopher G.;Parkes, Miles;Satsangi, Jack
通讯作者：
Satsangi, Jack
影响因子：
2.5
作者：
Strober W;Zhang F;Kitani A;Fuss I;Fichtner-Feigl S
通讯作者：
Fichtner-Feigl S
影响因子：
3.7
作者：
Hassan SW;Doody KM;Hardy S;Uetani N;Cournoyer D;Tremblay ML
通讯作者：
Tremblay ML