Mixed Connective Tissue Disease Developing into MPO-ANCA-positive Polyangiitis
Mixed Connective Tissue Disease Developing into MPO-ANCA-positive Polyangiitis
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DOI：
10.2169/internalmedicine.50.3958
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发表时间：
2011-01-01
影响因子：
1.2
通讯作者：
Matsumoto, Yoshihiro
中科院分区：
文献类型：
--
作者：
Murakami, Taichi;Endo, Shuichiro;Matsumoto, Yoshihiro
混合性结缔组织病（MCTD）肾脏受累表现为系统性红斑狼疮（SLE）样免疫复合物肾炎。这种情况的预后一般是好的。我们报告的情况下，老年女性患者与MCTD谁开发自身免疫性胸膜炎和快速进行性肾小球肾炎。髓过氧化物酶抗神经细胞胞浆抗体（MPO ANCA）阳性，滴度为59.0 EU。抗DNA抗体和补体水平正常。肾活检显示新月体肾小球肾炎和轻度系膜增生。然而，免疫荧光检查显示免疫复合物肾小球肾炎。这些结果表明，肾脏受累的MCTD发展的同时，MPO ANCA相关的肾小球肾炎。
Renal involvement of mixed connective tissue disease (MCTD) shows systemic lupus erythematosus (SLE)-like immune complex glomerulonephritis. The prognosis of this condition is generally good. We report the case of an elderly female patient with MCTD who developed autoimmune pleurisy and rapidly progressive glomerulonephritis. Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) was positive with a titer of 59.0 EU. Anti-DNA antibody and complement levels were normal. Renal biopsy revealed crescentic glomerulonephritis and mild mesangial proliferation. However, immunofluorescence examination revealed immune-complex glomerulonephritis. These findings suggest that the renal involvement of MCTD developed concurrently with MPO-ANCA-related glomerulonephritis.