Exploring type I angiotensin (AT1) receptor functions through gene targeting
Exploring type I angiotensin (AT1) receptor functions through gene targeting
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DOI：
10.1111/j.1365-201x.2004.01331.x
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发表时间：
2004-08-01
期刊：
影响因子：
--
通讯作者：
Coffman, TM
中科院分区：
文献类型：
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作者：
Crowley, SD;Tharaux, PL;Coffman, TM
肾素-血管紧张素系统（RAS）调节多种生理过程，包括发育、血压、肾功能和炎症。该系统的主要效应分子血管紧张素II介导大多数这些作用。RAS的经典识别功能是通过1型（AT（1））血管紧张素受体触发的。AT（1）受体的药理学阻断剂可降低血压并减缓心血管和肾脏疾病的进展。基因打靶技术为精确解剖RAS的生理功能提供了实验方法。在这里，我们回顾基因靶向实验如何阐明AT（1）受体的功能。
The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT(1)) class of angiotensin receptors. Pharmacological blockade of the AT(1) receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene-targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene-targeting experiments have elucidated AT(1) receptor functions.