The formation of aminorex in racehorses following levamisole administration. A quantitative and chiral analysis following synthetic aminorex or levamisole administration vs. aminorex-positive samples from the field: a preliminary report
The formation of aminorex in racehorses following levamisole administration. A quantitative and chiral analysis following synthetic aminorex or levamisole administration vs. aminorex-positive samples from the field: a preliminary report
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DOI：
10.1111/j.1365-2885.2008.01015.x
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发表时间：
2009-04-01
影响因子：
1.3
通讯作者：
Barker, S. A.
中科院分区：
文献类型：
--
作者：
Barker, S. A.
从2004年开始，赛马业经历了一场安非他明类药物氨基雷司阳性的流行病。对该药物阳性马的治疗性治疗研究表明，其来源是驱虫剂左旋咪唑给药。本研究检查了合成的外消旋氨基雷司给药后氨基雷司的尿液浓度随时间的变化。还提供了已知接受左旋咪唑给药的马的尿样中存在氨基雷司的确认，以及关于从田间采集的阳性样品中氨基雷司浓度和在相同样品中发现的左旋咪唑相应浓度的数据。此外，本研究表明，在田间样品中发现的氨基雷司的手性异构体分布与合成外消旋氨基雷司给药后的分布显著不同，与左旋咪唑给药后观察到的氨基雷司的手性异构体分布相似。检查氨基雷司的手性异构体分布和测定样品中是否存在左旋咪唑可用于评估氨基雷司阳性的来源，将其与有意合成的外消旋氨基雷司给药区分开来。还讨论了左旋咪唑在氨基雷克斯形成中的作用。
Beginning in 2004, the horseracing industry experienced an epidemic of drug positives for the amphetamine-like drug aminorex. Investigation of the therapeutic treatment of the horses called positive for this drug suggested that its source was from the administration of the anthelmintic levamisole. This study examines the urine concentrations of aminorex as a function of time following administration of synthetic, racemic aminorex. Confirmation of the presence of aminorex in urine samples from the horses known to be treated with levamisole is also presented as are data concerning the concentrations of aminorex in positives called from the field and the corresponding concentrations of levamisole found in the same samples. Furthermore, this study illustrates that the chiral isomer distribution of aminorex found in samples from the field is significantly different from that arising from the administration of synthetic, racemic aminorex and is similar to that observed from aminorex arising from levamisole administration. An examination of the chiral isomer distribution of aminorex and a determination of the presence of levamisole in a sample may be used to assess the source of an aminorex positive, distinguishing it from an intentional synthetic, racemic aminorex administration. The role of levamisole in aminorex formation is also discussed.