EFFERENT CONNECTIONS OF THE VENTRAL PALLIDUM - EVIDENCE OF A DUAL STRIATO PALLIDOFUGAL PATHWAY
EFFERENT CONNECTIONS OF THE VENTRAL PALLIDUM - EVIDENCE OF A DUAL STRIATO PALLIDOFUGAL PATHWAY
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DOI：
10.1002/cne.902350304
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
NAUTA, WJH
中科院分区：
文献类型：
--
作者：
HABER, SN;GROENEWEGEN, HJ;NAUTA, WJH
苍白球（苍白球外段），如传统划定在大鼠腹侧和吻侧下的前连合的横肢延伸，侵入嗅结节与其最腹侧的分支。苍白球或腹侧苍白球（VP）的这种连合下分部最有选择性地被P物质阳性离纹纤维的密集丛所弥漫;该丛的范围表明，前连合后面的VP继续背侧一段距离进入通常公认的前腹内侧部分。苍白球;相邻的前背外侧苍白球区（称为背侧苍白球（DP））仅接收少量P物质阳性纤维，但包含也弥漫VP的脑啡肽阳性纹状体传入的密集丛。VP和DP的纹状体神经支配来自纹状体的两个不同亚部;而VP由一个大的前腹内侧纹状体区支配，该区域接受来自各种边缘系统和边缘系统相关结构的大量输入（因此称为边缘纹状体），DP从只接受稀疏边缘传入的前背外侧纹状体区接受其纹状体输入（非边缘纹状体），但受到感觉运动皮质的严重神经支配。这种在纹状体苍白球投射中的二分法在很大程度上延续到苍白球之外; DP的传出纤维可追踪到丘脑底核和黑质，VP的传出纤维不仅可追踪到丘脑底核和黑质，还可追踪到额扣带回（和连接的内侧感觉运动）皮层、杏仁核、外侧缰核和丘脑背内侧核、下丘脑、腹侧被盖区，以及中脑中更远的尾侧和背侧的被盖区。腹侧苍白球不仅可以将边缘系统前体的纹状体苍白球流出物输送到锥体外系回路，还可以将其输送回边缘系统回路。
The globus pallidus (external pallidal segment) as conventionally delineated in the rat extends ventrally and rostrally beneath the transverse limb of the anterior commissure, invading the olfactory tubercle with its most ventral ramifications. This infracommissural subdivision of the globus pallidus or ventral pallidum (VP) is most selectively identified by being pervaded by a dense plexus of substance-P-positive striatofugal fibers; the extent of this plexus indicates that the VP behind the anterior commissure continues dorsally over some distance into the anteroventromedial part of the generally recognized (supracommissural) globus pallidus; the adjoining anterodorsolateral pallidal region, named dorsal pallidum (DP), receives only few substane-P-positive fibers, but contains a dense plexus of enkephalin-positive striatal afferents that also pervades VP. VP and DP receive their striatal innervation from 2 different subdivisions of the striatum; whereas VP is innervated by a large, anteroventromedial striatal region receiving substantial inputs from a variety of limbic and limbic-system-associated structures (and therefore called limbic striatum), DP receives its striatal input from an anterodorsolateral striatal sector receiving only sparse limbic afferents (nonlimbic striatum) but instead heavily innervated by the sensorimotor cortex. This dichotomy in the striatopallidal projection is to a large extent continued beyond the globus pallidus; whereas the efferents of DP were traced to the subthalamic nucleus and substantia nigra, those of VP involved not only the subthalamic nucleus and substantia nigra but also the frontocingulate (and ajoining medial sensorimotor) cortex, the amygdala, lateral habenular and mediodorsal thalamic nucleus, hypothalamus, ventral tegmental area, and tegmental regions farther caudal and dorsal in the midbrain. The ventral pallidum can convey striatopallidal outflow of limbic antecedents not only into extrapyramidal circuits but also back into the circuitry of the limbic system.