The effects of oral hydralazine on right ventricular end-diastolic pressure in patients with right ventricular failure.
The effects of oral hydralazine on right ventricular end-diastolic pressure in patients with right ventricular failure.
复制标题
口服肼屈嗪对右心衰竭患者右心室舒张末压的影响。
DOI：
10.1161/01.cir.65.7.1369
复制
发表时间：
1982
期刊：
影响因子：
37.8
通讯作者：
R. Peter
中科院分区：
文献类型：
--
作者：
L. Rubin;F. Handel;R. Peter
呋喃西林降低了原发性和继发性肺动脉高压患者的肺血管阻力，但阻力改变而不降低肺动脉压对右心功能的影响尚不清楚。我们观察了14例各种原因所致右心衰竭和肺动脉高压患者口服肼丙嗪50 mg，每6小时一次，连续48小时的血流动力学效应。肼丙嗪使平均右室舒张末压从17.45.6%降至11.65.3mmHg(p<0.001)，并使心输出量和每搏量增加超过40%。9例平均肺动脉压无变化的患者，总肺阻力由15.9±-6.0降至10.6+/-4.3(P<0.001)，心脏指数由2.07±-0.51升至2.97+/-0.91(P<0.005)。肺总阻力的降低与右室舒张末压力密切相关(r=0.73)。这些数据表明，即使在肺动脉压保持不变的情况下，呋喃西林也可以增加心输出量，降低右室舒张末压力。
Hydralazine reduces pulmonary vascular resistance in patients with primary and secondary pulmonary hypertension, but the effects on right ventricular function of a change in resistance without a reduction in pulmonary arterial pressure are not known. We evaluated the hemodynamic effects of hydralazine, 50 mg, administered orally every 6 hours for 48 hours in 14 patients with right ventricular failure and pulmonary hypertension resulting from various causes. Hydralazine reduced mean right ventricular end-diastolic pressure from 17.4 +/- 5.6 to 11.6 +/- 5.3 mm Hg (p less than 0.001) and increased cardiac output and stroke volume by more than 40%. In nine patients who had no change in mean pulmonary arterial pressure after hydralazine, total pulmonary resistance decreased from 15.9 +/- 6.0 to 10.6 +/- 4.3 (p less than 0.001) and cardiac index increased from 2.07 +/- 0.51 to 2.97 +/- 0.91 (p less than 0.005). There was a close correlation between the reductions in total pulmonary resistance and right ventricular end-diastolic pressure (r = 0.73)). These data suggest that hydralazine can increase cardiac output and reduce right ventricular end-diastolic pressure even when pulmonary arterial pressure remains unchanged.