MODELS FOR COMPUTER-SIMULATION STUDIES OF INPUT FUNCTIONS FOR TRACER KINETIC MODELING WITH POSITRON EMISSION TOMOGRAPHY
MODELS FOR COMPUTER-SIMULATION STUDIES OF INPUT FUNCTIONS FOR TRACER KINETIC MODELING WITH POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1016/0020-7101(93)90049-c
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发表时间：
1993-03-01
期刊：
影响因子：
--
通讯作者：
WANG, XM
中科院分区：
文献类型：
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作者：
FENG, D;HUANG, SC;WANG, XM
在正电子发射断层扫描（PET）示踪剂动力学建模中，直接测量（分段线性近似）示踪剂的血浆时间-活度曲线（PTAC）常被用作估计局部生理参数的输入函数。然而，没有明确的通用模型可用于PTAC本身，这限制了进一步研究PTAC，如PTAC测量噪声或PTAC采样时间表，对生理参数估计的影响。本文提出了一个PTAC模型，并与其他四种可能的候选人进行了比较。八组[F-18]-氟-2-脱氧-D-葡萄糖（FDG）的实验数据被用来测试模型和几个统计标准被用来验证其充分性。介绍了该模型在改善局部脑葡萄糖代谢率（LCMRGlc）估计方面的应用。该模型也有望用于生成逼真的PTAC曲线，在计算机模拟研究其他示踪剂及其动力学建模特性。
In tracer kinetic modeling with Positron Emission Tomography (PET), the direct measurement (piecewise linear approximation) of plasma time-activity curve of tracer (PTAC) is often used as the input function to estimate regional physiological parameters. However, no explicit general model is available for PTAC itself, which limits the further study of the effects of PTAC, such as PTAC measurement noise or PTAC sampling schedules, on the physiological parameters estimation. A PTAC model is proposed in this paper and compared with other four possible candidates. Eight sets of [F-18]-fluoro-2-deoxy-D-glucose (FDG) experimental data were used to test the models and several statistical criteria were used to validate their adequacy. An application of the model to improve the estimation of local cerebral metabolic rate of glucose (LCMRGlc) is presented. This model is also expected to be useful for generating realistic PTAC curves in computer simulation studies of other tracers and their kinetic modeling characteristics.