Intestinal superinfections in patients with inflammatory bowel diseases
Intestinal superinfections in patients with inflammatory bowel diseases
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DOI：
10.1016/j.crohns.2011.07.012
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发表时间：
2012-03-01
影响因子：
8
通讯作者：
Bassotti, Gabrio
中科院分区：
文献类型：
--
作者：
Antonelli, Elisabetta;Baldoni, Monia;Bassotti, Gabrio
背景资料：肠道二重感染可能发生在炎症性肠病（IBD）的背景下，使临床表现复杂化并引发疾病的爆发。目的：报告我们在IBD患者中发生肠道二重感染的三年经验。方法：对观察期间因中度至重度活动性疾病住院的患者的图表进行了审查，结果：113例IBD患者中，有15例（15/113（13.3%）有与肠道感染相关的突发事件;记录了143例急性发作，其中17例（12%）与感染性病原体有关，以空肠弯曲菌为代表（3例感染）、艰难梭菌（7例感染）和巨细胞病毒（7例感染）。除了两个感染都发生在溃疡性结肠炎患者，所有的反应适当treatment.Conclusions：肠道二重感染可能会使IBD患者的临床表现复杂化，增加诊断和治疗负担。因此，需要对这些患者采取适当的早期诊断和治疗措施。(C)2011年欧洲克罗恩病和结肠炎组织。Elsevier B. V.出版，保留所有权利。
Background: Intestinal superinfections may occur in the setting of inflammatory bowel diseases (IBD), complicating the clinical picture and triggering flares of disease.Aims: To report our experience with intestinal superinfections in IBD patients over a three-year period.Methods: Charts of patients hospitalized for moderate-to-severe active disease during the observation period were reviewed, and data of patients with flares due to infections collected and analyzed.Results: Overall, 15 out of 113 IBD patients (13.3%) had flare-ups related to intestinal infections; 143 acute flare-ups were thus documented, with 17 episodes (12%) related to infective agents, represented by Campylobacter jejuni (3 infections), Clostridium difficile (7 infections), and Cytomegalovirus (7 infections). All but two infections occurred in ulcerative colitis patients, and all responded to appropriate treatment.Conclusions: Intestinal superinfections may complicate the clinical picture of IBD patients, increasing the diagnostic and therapeutic burden. Appropriate early diagnostic and therapeutic measures are thus needed in these patients. (C) 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.