Premorbid physical activity predicts disability progression in relapsing-remitting multiple sclerosis
Premorbid physical activity predicts disability progression in relapsing-remitting multiple sclerosis
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DOI：
10.1016/j.jns.2012.08.033
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发表时间：
2012-12-15
影响因子：
4.4
通讯作者：
McAuley, Edward
中科院分区：
文献类型：
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作者：
Motl, Robert W.;Dlugonski, Deirdre;McAuley, Edward
背景：残疾进展是多发性硬化症(MS)的一个显著特征，已经通过各种人口统计学和临床变量以及疾病修饰疗法的治疗进行了预测。这项研究考察了病前体力活动作为复发缓解型多发性硬化症(RRMS)患者在24个月内残疾变化的预测因子。方法：269名RRMS患者完成了人口统计学和临床变量、病前和当前体力活动以及残疾状态的基线测量。在随后的24个月期间，每六个月进一步完成一次残疾衡量。数据用无条件和条件潜伏期增长曲线模型(LGCM)进行分析。结果：无条件潜伏期增长曲线模型显示残疾分数随着时间的推移呈显著的线性增加(p=.0015)。条件LGCM显示病前体力活动显著预测残疾分数的线性变化(标准化β=-0.23，p
Background: Disability progression is a hallmark feature of multiple sclerosis (MS) that has been predicted by a variety of demographic and clinical variables and treatment with disease modifying therapies. This study examined premorbid physical activity as a predictor of change in disability over 24 months in persons with relapsing-remitting MS (RRMS).Methods: 269 persons with RRMS completed baseline measures of demographic and clinical variables, premorbid and current physical activity, and disability status. The measure of disability was further completed every six months over the subsequent 24-month period. The data were analyzed with unconditional and conditional latent growth curve modeling (LGCM).Results: The unconditional LGCM indicated that there was a significant, linear increase in disability scores over time (p=.0015). The conditional LGCM indicated that premorbid physical activity significantly predicted the linear change in disability scores (standardized beta=-.23, p