Contact with animals and risk of oesophageal squamous cell carcinoma: outcome of a case-control study from Kashmir, a high-risk region
Contact with animals and risk of oesophageal squamous cell carcinoma: outcome of a case-control study from Kashmir, a high-risk region
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DOI：
10.1136/oemed-2013-101802
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发表时间：
2014-03-01
影响因子：
4.9
通讯作者：
Boffetta, Paolo
中科院分区：
文献类型：
--
作者：
Dar, Nazir Ahmad;Islami, Farhad;Boffetta, Paolo
一些研究报道了动物接触与某些癌症类型之间的关系，包括淋巴造血系统、结肠、胰腺和神经系统恶性肿瘤。我们的目的是调查动物接触和食管鳞状细胞癌（ESCC）的风险之间的关联在克什米尔，印度，ESCC的发病率相对较高的地区的病例对照研究。方法我们招募了703例组织学证实的ESCC病例和1664对照组分别匹配的情况下，年龄，性别和居住区。信息，包括动物接触，获得了面对面的访谈，使用结构化问卷。结果与不接触动物相比，每日密切接触与ESCC的风险增加相关（OR 5.99，95%CI 3.86 ~ 9.31），模型调整了几个潜在的混杂因素，包括社会经济状况的多个指标。这种关联在按综合财富得分和职业分层的亚组中持续存在。与动物的不定期接触与ESCC风险无关。动物接触持续时间与ESCC风险之间的相关性是混合的;然而，接触超过50年与风险增加相关（OR 3.10; 95% CI 1.53至6.26）。频率（趋势p，0.001）和持续时间（趋势p，
Background Several studies have reported association between animal contact and some cancer types, including lymphohaematopoietic, colon, pancreatic and neurological malignancies. We aimed to investigate the association between animal contact and risk of oesophageal squamous cell carcinoma (ESCC) in a case-control study in Kashmir, India, area with a relatively high incidence of ESCC.Methods We recruited 703 histologically confirmed ESCC cases and 1664 controls individually matched to the cases for age, sex and district of residence. Information, including on animal contact, was obtained in face-to-face interviews using a structured questionnaire. Conditional logistic regression models were used to calculate ORs and 95% CIs.Results As compared with no contact with animals, daily close contact was associated with an increased risk of ESCC (OR 5.99; 95% CI 3.86 to 9.31) in models adjusted for several potential confounding factors, including multiple indicators of socioeconomic status. This association persisted in subgroups following stratification by a composite wealth score and occupation. Irregular contact with animals was not associated with ESCC risk. The association between duration of animal contact and ESCC risk was mixed; however, contact for more than 50years was associated with an increased risk (OR 3.10; 95% CI 1.53 to 6.26). Frequency (p for trend, 0.001) and duration (p for trend,