Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies.
Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies.
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皮肤黑色素过度沉着：黄褐斑、壬二酸局部治疗和其他疗法。
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发表时间：
1996
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影响因子：
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通讯作者：
Breathnach As
中科院分区：
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作者：
Breathnach As
对黄褐斑患者的临床研究表明，局部使用 20% 壬二酸优于 2% 对苯二酚，且与 4% 对苯二酚一样有效，且没有后者的不良副作用。维甲酸似乎增强了壬二酸的这种作用。三个月后，与单独使用壬二酸相比，含有维A酸的壬二酸可带来更多的皮肤美白效果，并且在治疗结束时，优秀反应者的比例也更高。壬二酸的作用可归因于其抑制过度活跃的黑素细胞的能量产生和/或 DNA 合成的能力，部分归因于其抗酪氨酸酶活性。这也可能解释了对炎症后色素沉着过度的有益作用。通过相同活性的组合来破坏恶性黑素细胞，并通过肿瘤细胞对壬二酸的更大渗透性而增强，这可以解释在恶性雀斑样痣和原发性黑色素瘤的个别病变中观察到的壬二酸的临床效果。
Clinical studies of patients with melasma have shown that topical 20 percent azelaic acid is superior to 2 percent hydroquinone and as effective as 4 percent hydroquinone, without the latter's undesirable side effects. Tretinoin appears to enhance this effect of azelaic acid. Azelaic acid with tretinoin caused more skin lightening after three months than azelaic acid alone, and a higher proportion of excellent responders at the end of treatment. The effect of azelaic acid can be attributed to its ability to inhibit the energy production and/or DNA synthesis of hyperactive melanocytes, and partially to its antityrosinase activity. This may also account for the beneficial effect on postinflammatory hyperpigmentation. Destruction of malignant melanocytes by a combination of the same activities, enhanced by the greater permeability of tumoral cells to azelaic acid, may account for the clinical effects of azelaic acid observed in lentigo maligna and individual lesions of primary melanoma.