The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs.
The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs.
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c-mos 基因产物是小鼠卵减数分裂过程中细胞周期蛋白 B 积累所必需的。
DOI：
10.1073/pnas.88.17.7869
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发表时间：
1991
影响因子：
11.1
通讯作者：
Cooper,GM
中科院分区：
文献类型：
--
作者：
O'Keefe,SJ;Kiessling,AA;Cooper,GM
c-mos原癌基因表达为卵母细胞减数分裂所需的母体信息。通过对注射反义c-mos寡核苷酸的小鼠卵细胞进行分析，探讨了c-mos的作用机制。在反义注射的卵中，成熟促进因子在减数分裂I完成后没有被重新激活，导致在极体排出后2-3小时内形成含有去致密染色质的核。这与注射的卵不能积累新合成的细胞周期蛋白B有关。因此，c-mos原癌基因似乎影响调节小鼠卵子减数分裂期间细胞周期蛋白B稳定性的途径。
The c-mos protooncogene is expressed as a maternal message that is required for oocyte meiosis. The mechanism of action of c-mos was investigated by analysis of mouse eggs injected with antisense c-mos oligonucleotides. In antisense-injected eggs, maturation-promoting factor was not reactivated after the completion of meiosis I, leading to the formation of nuclei containing decondensed chromatin within 2-3 hr after polar body extrusion. This was correlated with a failure of the injected eggs to accumulate newly synthesized cyclin B. The c-mos protooncogene thus appears to affect the pathway that regulates cyclin B stability during meiosis of mouse eggs.