MENOPAUSE-RELATED CHANGES IN LIPOPROTEINS AND SOME OTHER CARDIOVASCULAR RISK-FACTORS
MENOPAUSE-RELATED CHANGES IN LIPOPROTEINS AND SOME OTHER CARDIOVASCULAR RISK-FACTORS
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DOI：
10.1093/ije/19.1.42
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发表时间：
1990-03-01
影响因子：
7.7
通讯作者：
GUIZE, L
中科院分区：
文献类型：
--
作者：
BONITHONKOPP, C;SCARABIN, PY;GUIZE, L
在对435名年龄在45-54岁之间未使用性激素的健康白色妇女进行的横断面研究中，检查了与绝经发生相关的血脂、脂蛋白和其他心血管危险因素的变化。单因素分析显示，绝经后妇女的总胆固醇、低密度脂蛋白胆固醇、载脂蛋白A1、载脂蛋白B、甘油三酯、收缩压和纤维蛋白原均显著高于绝经前妇女。高密度脂蛋白（HDL）胆固醇、舒张压和血糖不随绝经状态改变。在控制了混杂变量（年龄、体重指数和吸烟状况）的影响后，绝经后妇女的总胆固醇、LDL胆固醇、甘油三酯、载脂蛋白B和收缩压与绝经前妇女相比仍显著升高。我们的研究结果增加了流行病学证据，表明更年期会对脂质和脂蛋白代谢产生不利影响，从而可能增加患冠心病的风险。
Changes in lipids, lipoproteins and other cardiovascular risk factors associated with the occurrence of menopause have been examined in a cross-sectional study of 435 healthy white women, aged 45-54 years not using sex hormones. Univariate analysis showed that total cholesterol, low density lipoprotein (LDL) cholesterol, apolipoprotein A1, apolipoprotein B, triglycerides, systolic blood pressure and fibrinogen were significantly higher in post menopausal women than in premenopausal women. High density lipoprotein (HDL) cholesterol, diastolic blood pressure and blood glucose did not change with menopausal status. After controlling for the effects of confounding variables (age, body mass index and smoking status), total cholesterol, LDL cholesterol, triglycerides, apolipoprotein B and systolic blood pressure remained significantly increased in postmenopausal women as compared with premenopausal women. Our findings add to epidemiological evidence that menopause adversely affects the lipid and lipoprotein metabolism and thus, may increase the risk of coronary heart disease.