Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication
Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication
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DOI：
10.1038/ng.144
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发表时间：
2008-06-01
期刊：
影响因子：
30.8
通讯作者：
Tanksley, Steven D.
中科院分区：
文献类型：
--
作者：
Cong, Bin;Barrero, Luz S.;Tanksley, Steven D.
植物驯化代表了一种加速的进化形式，导致人类最感兴趣的组织和器官（例如种子，根和块茎）发生了夸张的变化。最极端的例子之一是番茄果实的进化。栽培番茄植株结出的果实比野生祖先的果实大1,000倍。数量性状图谱研究表明，相对较少的基因参与了这一戏剧性的转变，这些基因控制着两个过程：细胞周期和器官数量决定（1）。第一个过程中的关键基因已经被分离出来，对应于fw2.2，一种细胞分裂的负调控因子（2，3）。然而，到目前为止，对第二个过程的分子基础一无所知。在这里，我们表明，极端的果实大小的演变的第二个主要步骤是一个YABBY样转录因子（fasciated），控制心皮数在花和/或果实发育过程中的调节变化的结果。
Plant domestication represents an accelerated form of evolution, resulting in exaggerated changes in the tissues and organs of greatest interest to humans ( for example, seeds, roots and tubers). One of the most extreme cases has been the evolution of tomato fruit. Cultivated tomato plants produce fruit as much as 1,000 times larger than those of their wild progenitors. Quantitative trait mapping studies have shown that a relatively small number of genes were involved in this dramatic transition, and these genes control two processes: cell cycle and organ number determination(1). The key gene in the first process has been isolated and corresponds to fw2.2, a negative regulator of cell division(2,3). However, until now, nothing was known about the molecular basis of the second process. Here, we show that the second major step in the evolution of extreme fruit size was the result of a regulatory change of a YABBY-like transcription factor (fasciated) that controls carpel number during flower and/or fruit development.