Hirschsprung disease-Bowel function beyond childhood
Hirschsprung disease-Bowel function beyond childhood
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DOI：
10.1053/j.sempedsurg.2017.09.008
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发表时间：
2017-10-01
影响因子：
1.7
通讯作者：
Granstrom, Anna Lof
中科院分区：
文献类型：
--
作者：
Wester, Tomas;Granstrom, Anna Lof
先天性巨结肠是一种肠神经系统发育缺陷，其特征是后肠远端缺乏肠神经元。有许多关于短期结果的报告表明，肠功能受损是常见的。最近，几项对照研究表明，与健康对照受试者相比，青少年和成人的肠功能结果受到儿童期以后的影响。便秘和大便失禁是常见的。肠功能受损似乎对生活质量有负面影响，尽管大多数患者已适应其症状。另一方面，先天性巨结肠病似乎有有限的影响，教育和职业在成人life.This审查的目的是总结目前的知识，肠功能的结果超过儿童先天性巨结肠病患者。(C)2017爱思唯尔公司All rights reserved.
Hirschsprung disease is a developmental defect of the enteric nervous system characterized by lack of enteric neurons in the distal hindgut. There are numerous reports on short-term outcomes indicating that impaired bowel function is common. Recently, several controlled studies show that bowel function outcomes are affected beyond childhood, in adolescents and adults, compared with healthy control subjects. Constipation and fecal incontinence are common. The impaired bowel function appears to have a negative impact on quality of life, although, a majority of patients have adapted to their symptoms. On the other hand, Hirschsprung disease seems to have limited impact on education and occupation in adult life.The aim of this review was to summarize current knowledge of bowel function outcome beyond childhood in patients with Hirschsprung disease. (C) 2017 Elsevier Inc. All rights reserved.