RK-682, A POTENT INHIBITOR OF TYROSINE PHOSPHATASE, ARRESTED THE MAMMALIAN-CELL CYCLE PROGRESSION AT G(1)PHASE
RK-682, A POTENT INHIBITOR OF TYROSINE PHOSPHATASE, ARRESTED THE MAMMALIAN-CELL CYCLE PROGRESSION AT G(1)PHASE
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DOI：
10.1016/0014-5793(95)00953-7
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发表时间：
1995-09-18
期刊：
影响因子：
3.5
通讯作者：
OSADA, H
中科院分区：
文献类型：
--
作者：
HAMAGUCHI, T;SUDO, T;OSADA, H
A specific inhibitor of protein tyrosine phosphatase (PTPase), RK-682 (3-hexadecanoyl-5-hydrosymethyl-tetronic acid) was isolated from microbial metabolites, In vitro, RK-682 inhibited dephosphorylation activity of CD45 and VHR with IC50 54 and 2.0 mu M, respectively, In situ, sodium orthovanadate and RK-682 enhanced the phosphotyrosine level of Ball-1 cells, a human B cell leukemia, but not the phosphoserine/threonine level. The PTPase inhibitors, however, had the different arrest point on the cell cycle progression, Sodium orthovanadate inhibited the cell cycle progression at G(2)/M boundary phase, on the other hand, RK-682 inhibited the G(1)/S transition.
