Enhancement of photodynamic cancer therapy by physical and chemical factors.
Enhancement of photodynamic cancer therapy by physical and chemical factors.
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DOI：
10.1002/anie.201814098
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发表时间：
2019-07
影响因子：
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通讯作者：
Mingying Yang;Tao Yang;Chuanbin Mao
中科院分区：
文献类型：
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作者：
Mingying Yang;Tao Yang;Chuanbin Mao
由于光动力疗法（PDT）对健康组织的不良影响，其在癌症治疗中的可行用途从未完全实现。在这里，我们总结了一些物理化学因素，可以使光动力治疗更可行和有效的选择，以提供未来的肿瘤患者更好的治疗选择。这些物理化学因素包括光源、光敏剂（PS）载体、微波、电场、磁场和超声。这篇综述旨在提供有关PDT使用的最新信息，包括体外和体内研究的讨论。重点放在物理化学因素及其潜在的好处，在克服困难过渡到医疗领域的PDT。多种先进技术，如采用X射线作为光源，使用装载纳米颗粒的干细胞和噬菌体生物纳米线作为PS载体，以及与免疫疗法的整合，都是未来的发展方向。
The viable use of photodynamic therapy (PDT) in cancer therapy has never been fully realized due to its undesirable effects on healthy tissues. Here we summarize some physicochemical factors that can make PDT a more viable and effective option in order to provide future oncological patients with better-quality treatment options. These physicochemical factors include light sources, photosensitizer (PS) carriers, microwave, electric fields, magnetic fields, and ultrasound. This review is meant to provide current information pertaining to PDT use, including a discussion of in vitro and in vivo studies. Emphasis is placed on the physicochemical factors and their potential benefits in overcoming the difficulty in transitioning PDT into the medical field. Multiple advanced techniques, such as employing X-rays as a light source, using nanoparticle-loaded stem cells and bacteriophage bionanowires as a PS carrier, as well as integration with immunotherapy, are among the future directions.