Spatially resolved assessment of serotonin‐induced bronchoconstrictive responses in the rat lung using 3He ventilation MRI under spontaneous breathing conditions
Spatially resolved assessment of serotonin‐induced bronchoconstrictive responses in the rat lung using 3He ventilation MRI under spontaneous breathing conditions
复制标题
在自主呼吸条件下使用 3He 通气 MRI 对大鼠肺中血清素诱导的支气管收缩反应进行空间分辨评估
DOI：
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发表时间：
2010
影响因子：
3.3
通讯作者：
Y. Crémillieux
中科院分区：
文献类型：
--
作者：
K. Mosbah;V. Stupar;Y. Berthezène;N. Beckmann;Y. Crémillieux
使用超极化 3He MR 通气方案在自主呼吸的大鼠中对血清素（静脉注射 50 μg/kg 血清素）诱导的支气管收缩对肺通气的影响进行成像。评估气流阻塞的肺功能图是临床呼吸学的一个关键特征，源自吸入 3He 气体后获得的动态图像系列。使用回顾性电影图像重建程序获得跨越呼吸周期的动态通气 3He MR 图像。定义为信号幅度和最大信号衰减率的两个参数是从每个像素的 MR 信号的时间过程中得出的。这些参数对位于右肺和左肺下部的感兴趣区域进行平均，并进行统计分析。在参数彩色图上观察到每只大鼠注射血清素后信号幅度和最大信号衰减率均匀且显着降低。数据表明，动态通气 HP 3He MRI 可用于以空间分辨方式评估自主呼吸大鼠的通气功能以及引起短暂支气管收缩的药物的效果。 Magn Reson Med，2010。© 2010 Wiley-Liss, Inc.
The effect on lung ventilation of bronchoconstriction induced by serotonin (intravenous injection of 50 μg/kg of serotonin) was imaged using a hyperpolarized 3He MR ventilation protocol in spontaneously breathing rats. Lung function maps assessing airflow obstruction, a key feature in clinical pneumology, were derived from dynamic image series acquired after inhalation of 3He gas. Dynamic ventilation 3He MR images spanning a respiratory cycle were obtained using a retrospective cine image reconstruction procedure. Two parameters, defined as signal amplitude and maximum signal decay rate, were derived from the time course of the MR signal for each pixel. These parameters were averaged over regions of interest placed in the lower part of the right and left lungs and submitted to statistical analysis. A homogeneous and significant decrease of signal amplitude and maximum signal decay rate after serotonin injection was observed for each rat on the parametric color maps. The data indicate that dynamic ventilation HP 3He MRI can be used to assess, in a spatially resolved manner, the ventilation function of spontaneously breathing rats and the effects of agents eliciting short‐lasting bronchoconstriction. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
乙酰胆碱引起反射性支气管收缩。
DOI：
10.1152/jappl.1999.86.1.294
发表时间：
1999
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Wagner,EM;Jacoby,DB
通讯作者：
Jacoby,DB