Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure.
Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure.
复制标题
大鼠中通过血管收缩剂或水浸泡释放的心房肽与右心房压力的变化相关。
DOI：
10.1016/0006-291x(85)91226-4
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
Philip Needleman
中科院分区：
文献类型：
--
作者：
Nobuo C. Katsube;David J. Schwartz;Philip Needleman
加压素，其1-脱氨基类似物（dAVP），血管紧张素II，和苯肾上腺素，静脉给药，增加水合氯醛麻醉大鼠血浆心房肽免疫反应性。连续1小时输注dAVP或苯肾上腺素引起以下方面的持续升高：a）全身血压; B）右心房压力; c）左心室舒张末期压力;和d）血浆心房肽免疫反应性。虽然连续输注血管紧张素II也产生了持续的左心室舒张末期压升高，右心房压力和血浆心房肽素的变化只是短暂的。这些数据表明，血浆心房肽最密切相关的右心房压力。与这一假设相一致，我们发现，在麻醉，水浸大鼠右心房压力的变化与心房肽素的释放直接相关。
Vasopressin, its 1-deamino analog (dAVP), angiotensin II, and phenylephrine, administered intravenously, increased plasma atriopeptin immunoreactivity in chloral hydrate-anesthetized rats. A continuous one hour infusion of either dAVP or phenylephrine caused a sustained elevation in: a) systemic blood pressure; b) right atrial pressure; c) left ventricular end diastolic pressure; and d) plasma atriopeptin immunoreactivity. While continuous infusion of angiotensin II also produced a sustained elevation in left ventricular end diastolic pressure, the changes in right atrial pressure and plasma atriopeptin were only transient. These data suggest that plasma atriopeptin most closely correlates with right atrial pressure. Consistent with this hypothesis, we found that the release of atriopeptin directly correlated with changes in right atrial pressure in anesthetized, water-immersed rats.