Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
复制标题
补充初乳和母乳中的双歧杆菌可增强极早产儿的体重增加和与微生物群建立相关的代谢反应
作者：
T. Oshiro;S. Nagata;Chongxin Wang;Takuya Takahashi;H. Tsuji;T. Asahara;K. Nomoto;H. Takei;H. Nittono;Y. Yamashiro
背景：极早产儿（VPI）的出生后生长受限可能具有长期影响。最近的证据表明，VPIs的发育问题与肠道微生物群落的异常有关。目的：探讨双歧杆菌沿着添加于母乳和初乳中对营养不良儿童生长发育的影响。方法：对35例出生体重<1，500 g，孕24 ~ 31周的VPI进行随机对照研究。患者每日接受短双歧杆菌补充剂（双歧杆菌组）或仅接受载体补充剂（安慰剂组）。所有婴儿在出生后不久开始肠外营养，包括葡萄糖、氨基酸和脂肪酸。每个婴儿在出生后24小时内接受自己母亲的初乳，并在随后的几天接受母乳。分析粪便细菌、有机酸、pH、胆汁酸和血浆脂肪酸。结果如下：17名婴儿被分配到Biofluoride组，18名婴儿被分配到安慰剂组;两组之间的出生体重和胎龄没有显著差异。与安慰剂组相比，Biofluoride组在8周时体重增加显著更大且更早;粪便细菌总数（包括Biofluoride细菌）显著更高;粪便总短链脂肪酸水平更高，血浆n-3脂肪酸浓度名义上（但不显著）更高;粪便总胆汁酸水平更低。结论：母体初乳和母乳的生物可降解细菌补充产生了有益的微生物群特征的建立，导致有利的代谢反应，似乎提供了改善的VPI生长。
Background: Postnatal growth restriction in very-preterm infants (VPIs) may have long-lasting effects. Recent evidence suggests that developmental problems in VPIs are related to abnormalities in intestinal microbial communities. Objective: To investigate the effect on growth outcomes in VPIs of supplementation with Bifidobacterium along with mother’s colostrum and breast milk. Methods: A randomized controlled study was performed on 35 VPIs, born between 24 and 31 weeks of gestation with birth weights <1,500 g. The patients received either daily Bifidobacterium breve supplementation (Bifid group) or vehicle supplement only (placebo group). Parenteral nutrition was initiated with glucose, amino acids, and fatty acids for all of the infants soon after birth. Each infant received their own mother’s colostrum within 24 h of birth, and breast milk on subsequent days. Fecal bacteria, organic acids, pH, bile acids, and plasma fatty acids were analyzed. Results: Seventeen infants were allocated to the Bifid group and 18 to the placebo group; the birth weights and gestational ages did not differ significantly between the two groups. Compared to the placebo group, the Bifid group showed significantly greater and earlier weight gain by 8 weeks; significantly higher total fecal bacterial counts, including bifidobacteria; higher levels of total fecal short-chain fatty acids and nominally (but not significantly) higher concentrations of plasma n–3 fatty acids; and lower levels of total fecal bile acid. Conclusions: Bifidobacterial supplementation of maternal colostrum and breast milk yielded the establishment of a beneficial microbiota profile, leading to favorable metabolic responses that appeared to provide improved growth in VPIs.
影响因子：
120.7
作者：
Stoll, BJ;Hansen, NI;Higgins, RD
通讯作者：
Higgins, RD