RECEPTOR-MEDIATED TRANSCYTOSIS OF TRANSFERRIN ACROSS THE BLOOD-BRAIN-BARRIER
RECEPTOR-MEDIATED TRANSCYTOSIS OF TRANSFERRIN ACROSS THE BLOOD-BRAIN-BARRIER
复制标题
DOI：
10.1002/jnr.490180206
复制
发表时间：
1987-01-01
影响因子：
4.2
通讯作者：
FINE, RE
中科院分区：
文献类型：
--
作者：
FISHMAN, JB;RUBIN, JB;FINE, RE
用125 I-转铁蛋白灌注大鼠脑导致转铁蛋白受体介导的摄取进入血脑屏障内皮，随后在脑中检测到转铁蛋白。在脉冲追逐实验中，125 I-转铁蛋白积累在内皮细胞中的脉冲过程中，与此内皮内的放射性减少，在追逐过程中与伴随的增加，在大脑的非血管元素。受体介导的运铁蛋白穿过血脑屏障的运动表明，大脑可以通过跨脑微血管系统的铁载转铁蛋白的转胞吞作用来获得其铁。我们讨论的可能性，铝和其他潜在的有毒重金属，也紧密结合转铁蛋白，可能进入大脑通过这一途径。我们还讨论了其他大分子，包括神经活性肽和神经营养病毒可能通过类似的受体介导的，囊泡胞吞途径进入大脑的可能性。
The perfusion of rat brain with 125I-transferrin resulted in a receptor-mediated uptake of transferrin into the endothelium of the blood-brain barrier followed by its detection in the brain. During a pulse-chase experiment, 125I-transferrin accumulated in the endothelial cells during the pulse, with a decrease of this intraendothelial radioactivity during the chase associated with a concomitant increase in the nonvascular elements of the brain. The receptor-mediated movement of transferrin across the blood-brain barrier suggests that the brain may derive its iron through the transcytosis of iron-loaded transferrin across the brain microvasculature. We discuss the likelihood that aluminum and other potentially toxic heavy metals, which also bind tightly to transferrin, may enter the brain by this pathway. We also discuss the possibility that other large molecules including neuroactive peptides and neurotrophic viruses may enter the brain through a similar receptor-mediated, vesicular transcytotic route.