Simultaneous measurement of cardiac output and its distribution with microspheres in the rat.
Simultaneous measurement of cardiac output and its distribution with microspheres in the rat.
复制标题
用微球同时测量大鼠心输出量及其分布。
作者：
Denis G. McDevitt;A. S. Nies
放射性微球法用于通过使用在微球分布期间获得的动脉参考样品来估计心输出量及其在同一大鼠中的分布。注射足够的微球，使得所有计数的样品含有超过400个微球。微球注射过程中无血流动力学变化。心输出量为253 +/- 11 ml/min/kg体重的结果与使用其他技术的已发表估计值一致。心输出量的分布也与大多数已发表的报告一致。当需要心输出量和器官血流量时，该方法可方便地将大鼠用于某些血液动力学研究。
The radioactive microsphere method was used to estimate simultaneoulsy the cardiac output and its distribution in the same rat by the use of an arterial reference sample obtained during microsphere distribution. Sufficient microspheres were injected so that all counted samples contained more than 400 spheres. No haemodynamic changes occurred during microsphere injection. The results for cardiac output of 253 +/- 11 ml/min per kg body weight agree with published estimates utilizing other techniques. The distribution of cardiac output also agrees with most published reports. This method should allow the rat to be conveniently used for certain haemodynamic studies when cardiac output and organ blood flow are necessary.