Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study
Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study
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DOI：
10.1016/j.fertnstert.2006.02.070
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发表时间：
2006-06-01
影响因子：
6.7
通讯作者：
Kim, Seok Hyun
中科院分区：
文献类型：
--
作者：
Jee, Byung Chul;Ku, Seung Yup;Kim, Seok Hyun
目的：比较来曲唑和克罗米芬（CC）在促性腺激素联合宫腔内人工授精（IUI）研究中的临床结局。设计：前瞻性试点研究。设置：一所大学医院和两个私人不孕症诊所。患者：93对符合超排卵和IUI的不孕夫妇。干预：在月经周期的第3-7天给予2.5 mg/天的来曲唑剂量（n = 66）或100 mg/天的CC剂量（n = 27），从第5天开始每隔一天联合给予150 IU剂量的人绝经期促性腺激素（hMG）。结果：两组患者的临床特征相似。来曲唑组的成熟卵泡数量（3.2 +/- 1.7 vs. 5.6 +/- 2.4）和hCG当天的血清E-2水平（231.0 +/- 179.8 vs. 1，371.7 +/- 750.5 PG/mL）显著较低。在hCG当天测量的子宫内膜厚度或临床妊娠率（18.2% vs. 25.9%）无显著差异。来曲唑组在hCG日血清P水平> 1.0 ng/mL的患者比例显著低于来曲唑组（4.5%vs.25.9%）。结论：在促性腺激素联合IUI周期中，来曲唑与CC的妊娠率相当。我们的结果应该在更大的人群中通过适当的随机化得到证实。
Objective: To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) study.Design: Prospective pilot study.Setting: One university hospital and two private infertility clinics.Patient(s): Ninety-three infertile couples eligible for superovulation and IUI.Intervention(s): A letrozole dose of 2.5 mg/day (n = 66) or a CC dose of 100 mg/day (n = 27) was given on day 3-7 of the menstral cycle, combined with human menopausal gonadotropin (hMG) at a dose 150 IU every other day starting on day 5.Main Outcome Measures(s): The number of mature follicles, serum estradiol (E-2) and progesterone (P) levels, endometriel thicknesses on the day of human chorionic gonadotropin (hCG), and clinical pregnancy rates.Result(s): The patients' clinical characteristics were comparable between the two groups. The number of mature follicles (3.2 +/- 1.7 vs. 5.6 +/- 2.4) and serum E-2 levels on the day of hCG (231.0 +/- 179.8) vs. 1,371.7 +/- 750.5 PG/mL) were significantly lower in the letrozole group. No significant differences were in endometrial thickness measured on the day of hCG or clinical pregnancy rates (18.2% vs. 25.9%). The rate of patients with serum P levels > 1.0 ng/mL on the day of hCG was significantly lower in the letrozole group (4.5% vs. 25.9%).Conclusion(s): Letrozole produced a comparable pregnancy rate vs. CC in gonadotropin-combined IUI cycles. Our results should be confirmed in larger populations with proper randomization.