Rapid prototyping method for 3D PDMS microfluidic devices using a red femtosecond laser
Rapid prototyping method for 3D PDMS microfluidic devices using a red femtosecond laser
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DOI：
10.1177/1687814020982713
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发表时间：
2020-12-01
影响因子：
2.1
通讯作者：
Hajiyavand, Amir M.
中科院分区：
文献类型：
--
作者：
Saadat, Mozafar;Taylor, Marie;Hajiyavand, Amir M.
演示了一种快速原型技术，该技术使用红色飞秒激光生产金属模具，然后直接用于 PDMS 的复制成型。制造过程可以在不到 6 小时内完成，这使其成为快速测试新设计的可行技术。该技术通过创建通道高度和深度均为 300 μm 的微流体装置进行验证，并具有斜坡测试结构，其中通道的高度和宽度减小至 100 μm，以展示该技术的 3D 功能。由此产生的 PDMS 器件可以轻松地从金属模具中取出，并且除了热固化过程中预期的收缩之外，还可以精确地复制形状。由于该技术使用单一复制工艺，通道底部的表面粗糙度对应于未烧蚀抛光的金属模具，从而产生 0.361 nm 的极低表面粗糙度。烧蚀的金属模具表面对应于 PDMS 装置的顶部，该装置与玻璃粘合，不会影响通道内的流动，从而减少了优化激光参数的需要。最后，通过演示无滑移条件下的层流来验证该装置。
A rapid prototyping technique is demonstrated which uses a red femtosecond laser to produce a metallic mould which is then directly used for the replica moulding of PDMS. The manufacturing process can be completed in less than 6 h making it a viable technique for testing new designs quickly. The technique is validated by creating a microfluidic device with channels of height and depth of 300 mu m, with a ramp test structure where the height and width of the channels reduces to 100 mu m to demonstrate the techniques 3D capabilities. The resulting PDMS device was easily removed from the metallic mould and closely replicated the shape aside the expected shrinkage during thermal curing. As the technique uses a single replica process, the surface roughness at the base of the channels corresponds to the un-ablated polished metal mould, resulting in a very low surface roughness of 0.361 nm. The ablated metallic mould surface corresponds to the top of the PDMS device, which is bonded to glass and does not affect the flow within the channels, reducing the need for optimisation of laser parameters. Finally, the device is validated by demonstrating laminar flow with the no-slip condition.