Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells
Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells
复制标题
用于高性能富集循环肿瘤细胞的仿生免疫磁小体
DOI：
10.1002/adma.201601643
复制
发表时间：
2016-09-28
影响因子：
29.4
通讯作者：
Xie, Hai-Yan
中科院分区：
文献类型：
--
作者：
Xiong, Ke;Wei, Wei;Xie, Hai-Yan
A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.
