Progress in Typhoid Fever Epidemiology
Progress in Typhoid Fever Epidemiology
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DOI：
10.1093/cid/ciy846
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发表时间：
2019-02-15
影响因子：
11.8
通讯作者：
Crump, John A.
中科院分区：
文献类型：
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作者：
Crump, John A.
伤寒沙门氏菌（Salmonella typhi）是伤寒的病原菌，也是一种人类宿主限制性微生物。近几十年来，随着高质量伤寒发病率研究的数量和地理代表性的增加，以及建模方法的更加复杂，我们对伤寒全球负担的理解有所提高。2017年世界卫生组织免疫战略咨询专家组建议在伤寒流行国家为6个月以上的婴儿和儿童引入伤寒结合疫苗，这可能需要我们在全球和国家层面进一步提高对伤寒负担的理解。此外，认识到水和卫生条件的改善与疫苗的引进相一致的关键和协同作用，强调了提高我们对伤寒沙门氏菌在不同环境中传播的来源、模式和方式的理解的重要性。
Salmonella enterica subspecies enterica serovar Typhi (Salmonella Typhi) is the cause of typhoid fever and a human host-restricted organism. Our understanding of the global burden of typhoid fever has improved in recent decades, with both an increase in the number and geographic representation of high-quality typhoid fever incidence studies, and greater sophistication of modeling approaches. The 2017 World Health Organization Strategic Advisory Group of Experts on Immunization recommendation for the introduction of typhoid conjugate vaccines for infants and children aged >6 months in typhoid-endemic countries is likely to require further improvements in our understanding of typhoid burden at the global and national levels. Furthermore, the recognition of the critical and synergistic role of water and sanitation improvements in concert with vaccine introduction emphasize the importance of improving our understanding of the sources, patterns, and modes of transmission of Salmonella Typhi in diverse settings.