Greater Early Gains in Fat-Free Mass, but Not Fat Mass, Are Associated with Improved Neurodevelopment at 1 Year Corrected Age for Prematurity in Very Low Birth Weight Preterm Infants
Greater Early Gains in Fat-Free Mass, but Not Fat Mass, Are Associated with Improved Neurodevelopment at 1 Year Corrected Age for Prematurity in Very Low Birth Weight Preterm Infants
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DOI：
10.1016/j.jpeds.2016.03.003
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发表时间：
2016-06-01
影响因子：
5.1
通讯作者：
Demerath, Ellen W.
中科院分区：
文献类型：
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作者：
Ramel, Sara E.;Gray, Heather L.;Demerath, Ellen W.
目的探讨早产儿早期体成分变化与1岁时神经发育之间的关系。研究设计：采用空气置换体积描记法对34例极低出生体重早产儿进行前瞻性、纵向研究，从出生后稳定至出院，每周测量一次体成分。在12个月CA时进行神经发育测试（Bayley婴儿发育量表-III）。使用线性混合效应模型获得住院受试者特定的无脂肪质量（FFM）和脂肪质量（FM）变化，然后将其用作后续线性回归模型中Bayley子量表评分的预测因子，并对潜在混杂因素进行调整。蛋白质和能量供应计算的第一个week的life.Results更大的FFM收益，而住院与改善认知和运动评分在12个月CA（P = 0.002）。当校正出生体重、胎龄和脑室内出血时，这些关系仍然显著（P
Objective This work investigates the relationship between early body composition changes and neurodevelopment at 1 year age corrected for prematurity (CA).Study design A prospective, longitudinal study to measure body composition weekly in 34 very low birth weight preterm infants using air displacement plethysmography, beginning when infants stabilized after birth until discharge. Neurodevelopmental testing (Bayley Scales of Infant Development-III) was performed at 12 months CA. Linear mixed effects models were used to obtain inpatient subject-specific changes in fat-free mass (FFM) and fat mass (FM), which were then used as predictors of Bayley subscale scores in subsequent linear regression models, adjusting for potential confounders. Protein and energy provision were calculated for the first week of life.Results Greater FFM gains while inpatient were associated with improved cognitive and motor scores at 12 months CA (P = .002 for both). These relationships remained significant when adjusting for birth weight, gestational age, and intraventricular hemorrhage (P