OLFACTORY-BULB EXCITABILITY SELECTIVELY MODIFIED IN BEHAVING RATS AFTER LOCAL 6-HYDROXYDOPAMINE TREATMENT
OLFACTORY-BULB EXCITABILITY SELECTIVELY MODIFIED IN BEHAVING RATS AFTER LOCAL 6-HYDROXYDOPAMINE TREATMENT
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DOI：
10.1016/0166-4328(83)90126-2
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发表时间：
1983-01-01
影响因子：
2.7
通讯作者：
PAGER, J
中科院分区：
文献类型：
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作者：
GERVAIS, R;PAGER, J
嗅球（OB）的反应性可能会选择性地增强对食物气味在自由移动饥饿大鼠。这种嗅觉输入的调制依赖于离心纤维的作用。从蓝斑到OB的去甲肾上腺素能（NA）投射可能参与OB兴奋性的适应性控制。在阻塞嗅腔后，17只大鼠接受将6-羟基多巴胺[6-OHDA]溶液（10 μ g盐; 40 nmol游离碱）离散注射到1 OB（6-OHDA球）中，并将载体注射到对侧（对照球）中; 10只假手术大鼠接受双侧注射的球内等渗盐水溶液（假球）。在去甲肾上腺素含量显著降低的12个6-OHDA灯泡中，平均多巴胺和去甲肾上腺素水平分别为对照值的90%和34%。治疗后一周，6-OHDA治疗组动物的平均易怒评分显著高于假手术组。治疗的主要电生理效应是放大OB对饥饿动物中通常发生的食物气味的反应的选择性增强;这种效应仅限于6-OHDA灯泡。考虑到可能参与NA纤维的选择性注意气味在OB水平的结果进行了讨论。
Olfactory bulb (OB) responsiveness may be selectively enhanced towards food odor in free-moving hungry rats. This modulation of the olfactory input depended on the action of centrifugal fibers. The possible involvement of the noradrenergic (NA) projections from the locus coeruleus to the OB in this adaptative control of the OB excitability was investigated. After plugging of the olfactory lumen, 17 rats received discrete injections of 6-hydroxydopamine [6-OHDA] solution (10 .mu.g of the salt; 40 nmol free base) into 1 OB (6-OHDA bulb) and the vehicle into the contralateral side (control bulb); 10 sham operated rats received intrabulbar isotonic saline solution injected bilaterally (sham bulbs). In the 12 6-OHDA bulbs with the noradrenaline [norepinephrine] content significantly reduced the mean dopamine and noradrenaline levels were, respectively, 90 and 34% of the control values. One week after treatment, the average irritability score was significantly higher in the 6-OHDA treated animals than in the sham-operated ones. The main electrophysiological effect of the treatment was to amplify the selective enhancement of OB responsiveness to food odor normally occurring in hungry animals; this effect was restricted to the 6-OHDA bulbs. The results are discussed considering the possible involvement of NA fibers in selective attention to odors at the OB level.