A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates.
A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates.
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一种从活化的核苷氨基磷酸酯制备核苷三磷酸的新方法。
DOI：
10.1021/ol049267j
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Borch,RichardF
中科院分区：
文献类型：
--
作者：
Wu,Weidong;FreelMeyers,CarenL;Borch,RichardF
提出了一种制备三磷酸核苷的新方法。该策略采用高活性的磷酸吡啶两性离子中间体，与三（四正丁基铵）焦磷酸氢有效偶联，生成三磷酸核苷。
A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.