A Rare Case of HPV-Negative Cervical Squamous Cell Carcinoma
A Rare Case of HPV-Negative Cervical Squamous Cell Carcinoma
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DOI：
10.1097/pgp.0000000000000132
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发表时间：
2015-03-01
影响因子：
2.4
通讯作者：
McCluggage, W. Glenn
中科院分区：
文献类型：
--
作者：
Casey, Shauna;Harley, Ian;McCluggage, W. Glenn
一般认为，几乎所有的宫颈鳞状细胞癌都与高危型人乳头瘤病毒（HPV）的持续感染有关，尽管众所周知，宫颈腺癌的不寻常变体大多是HPV阴性的。我们报告一个54岁女性的高分化子宫颈鳞状细胞癌病例，其形态学特征提示非HPV相关肿瘤。肿瘤为p16阴性。HPV也是阴性的2种方法，包括高度敏感的SPF-10系统。需要进一步研究其他病例以确定非常罕见的非HPV相关宫颈鳞状细胞癌的病因和发病因素。
It is generally assumed that virtually all cervical squamous cell carcinomas are associated with persistent infection by high-risk human papillomavirus (HPV), although it is well known that unusual variants of cervical adenocarcinoma are mostly HPV negative. We report a case of a well-differentiated cervical squamous cell carcinoma in a 54-yr-old woman, the morphologic features of which suggested a non-HPV-related neoplasm. The tumor was p16 negative. HPV was also negative by 2 methods, including the highly sensitive SPF-10 system. Further study of additional cases is needed to establish the etiological and pathogenetic factors that underlie very rare non-HPV-related cervical squamous cell carcinoma.