Performance of mice in discrimination of liquor odors: Behavioral evidence for olfactory attention
Performance of mice in discrimination of liquor odors: Behavioral evidence for olfactory attention
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DOI：
10.1093/chemse/bjm086
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发表时间：
2008-03-01
期刊：
影响因子：
3.5
通讯作者：
Ohtake, Hisao
中科院分区：
文献类型：
--
作者：
Takiguchi, Noboru;Okuhara, Keisuke;Ohtake, Hisao
我们通过Y迷宫行为学测试了小鼠对白酒气味的辨别能力。起初，口渴的小鼠被训练在Y形迷宫中选择红酒的气味。经过成功的训练(每只受训的小鼠有70%的符合率)，每只小鼠能够将所学到的红酒与其他酒区分开来，包括白葡萄酒、玫瑰葡萄酒、清酒和梅子利口酒。然而，当小鼠被测试来区分两个品牌的红酒之间的细微差异时，它们的表现在单独训练的小鼠中存在显著差异。在接受测试的10只小鼠中，2只小鼠能够分辨出红葡萄酒(>；75%的一致性)，而6只小鼠无法区分它们(50%-67%的一致性，可以假设有50%的几率)。更重要的是，另外两只小鼠表现出低于30%的一致性，这表明它们比学习的小鼠更喜欢没有奖励的红酒。这一结果表明，当训练小鼠在Y形迷宫中选择酒的气味时，个别小鼠将注意力集中到从奖励的红酒中发出的不同挥发性成分。在使用3种或更少纯气味混合物的Y迷宫行为测试中，也观察到小鼠的选择性注意。此外，我们还观察到，小鼠的嗅觉注意可以通过它们的学习经历来改变。
We examined performance of mice in discrimination of liquor odors by Y-maze behavioral assays. Thirsty mice were initially trained to choose the odor of a red wine in the Y-maze. After successful training (> 70% concordance for each trained mouse), the individual mice were able to discriminate the learned red wine from other liquors, including white wine, rose wine, sake, and plum liqueur. However, when the mice were tested to distinguish fine differences between 2 brands of red wine, their performance significantly varied among the individual trained mice. Among 10 mice tested, 2 mice were able to discriminate between the red wines (> 75% concordance) whereas 6 mice failed to distinguish between them (50-67% concordance, where chance could be assumed to be 50%). More importantly, 2 other mice exhibited lower than 30% concordance, indicating that they were more attracted to the nonrewarded red wine compared with the learned one. This result suggested that the individual mice directed attention to different subsets of volatile components emanating from the rewarded red wine, when they were trained to choose the liquor odor in the Y-maze. Selective attention of mice was also observed in Y-maze behavioral assays using the mixtures of 3 or less pure odorants. Additionally, we also observed that the olfactory attention of mice could be modified through their learning experiences.